This reference shows the reader how to examine a compound's pharmaceutical properties, emphasizing oral absorption. It also explains the different physicochemical methods currently used to analyze drug candidates and how to interpret these methods.

Featured Topics:

• The physicochemical needs of pharmaceutical research and development
• The flux model in terms of solubility, permeability, and charge state (pH)
• Ionization constants
• Experimental methods of measuring partition coefficients, log P and log D
• Partition coefficients where the lipid phase is made of liposomes formed from vesicles of bilayers of phospholipids
• Experimental methods of measuring solubility
• PAMPA (parallel artificial membrane permeability assays

Absorption and Drug Development helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.

Also included are physicochemical data for over 200 commercial drugs. With over 600 references and 100 drawings, this book is an excellent resource for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.

Contents

1. Definitions
2. Introduction
3. Transport Model
4. Charge State
5. Partitioning Into Octanol
6. Partitioning Into Liposomes
7. Solubility
8. Permeability
9. Summary and Some Simple Rules

Index

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