Features:

• Explores the mathematical foundation that underpins the concepts

• Contains numerous graphs and extensive, worked-out explanations of equations

• Discusses the latest advances in the use of polymers in dosage forms

• Includes a detailed review and analysis of dosage form design criteria

Discussing comprehensive range of topics, Advanced Pharmaceutics reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms.

Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used.

Advanced Pharmaceutics provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.

Contents

1. Thermodynamics
   
   • Ideal Gases
   • Real Gases
   • Thermodynamics
   • Free Energy

2. Ionic Equilibrium
   
   • Strong Acids and Bases
   • Monoprotic Weak Acids and Weak Bases
   • Polyprotic Weak Acids and Weak Bases
   • Sparingly Soluble Salts

3. Solutions and Distribution
   
   • Solutions of Solids and Non-volatile Liquids in Liquids
   • Solutions of Volatile Liquids in Liquids
   • Solutions of Gases in Liquids (Henry's Law)
   • Colligative Properties
   • Distribution Law (Partition Coefficient)

4. Surface Chemistry and Colloids
   
   • Adsorption from Solutions
   • Liquid Liquid Systems (Emulsions)
   • Solid Liquid Systems (Suspensions)

5. Kinetics
   
   • Pathways of Drug Degradation
   • Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions
   • Irreversible Reactions
   • Determination of the Order of Reaction and Its Rate Constant
   • Other Irreversible Reactions
   • Reversible Reactions
   • Reversible and Series Reactions (Eigenvalue Method)
   • Use of Laplace Transform for Differential Rate Equations
   • Enzyme Substrate Reactions
   • Acid Base Catalyzed Degradation Kinetics
   • Oxidation (Free Radical Reaction)
   • Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes
   • Temperature Effects on Reaction Rate Constants

6. Diffusion
   
   • Diffusion
   • Diffusion Through a Membrane
   • Diffusion in a Monolithic Matrix
   • Diffusion in a Membrane Matrix System
   • Diffusion During the Swelling of Matrix
   • Diffusion in a Matrix Erosion/Degradation
   • Diffusion in a Matrix Swelling/Erosion
   • Diffusion with Chemical Reaction in a Membrane
   • Surface Area and Concentration Gradient Systems
   • Osmotically Controlled Systems

7. Polymer Science
   
   • Classification of Polymers
   • Molecular Weight and Molecular Weight Distribution of Polymers
   • Characterization of Polymers
   • Polymer Synthesis
   • Natural Polymers and Their Modification

Index

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