Analytical Methods
in Combinatorial Chemistry
by Bing Yan

This book contains most analytical methods that have been applied to solving various problems in broad areas of combinatorial chemistry, chemistry optimization, library synthesis, lead selection, and lead optimization.

Examples related to solid-phase peptide synthesis are included with an emphasis on their implication for the small molecule synthesis.

This book serves as a valuable companion and a comprehensive reference book for chemists involved in combinatorial chemistry. Also as an introduction to lead beginners to enter the field of combinatorial chemistry knowing every analytical issue and possible solution.

For those interested in analytical chemistry, this book tries to include as many research possibilities and directions as can be achieved.

Contents

1. Analytical Issues in Combinatorial Chemistry
   
   Combinatorial Chemistry
   Synthesis Methods
   Analytical Challenges
   
   
2. An Examination of the Analytical Sample: Resin Support
   
   Physical Properties of Resins
   Resin Swelling and Solvation
   Effects of the Solvated Resiin on Solid-Phase Reactions
   
   
3. Solid-Phase Reaction Optimization Using FTIR Methods
   
   Comparison of FTIR and Raman Techniques
   Monitoring of Reaction on Polystyrene-Based Resin
   Monitoring of Reaction on PS-Peg Resins: Comparing the Reaction Rate on PS and PS-Peg Resins
   Monitoring of Reactions on Surface-Fuctionalized Polymers
   
   
4. Reaction Optimization Using MS and NMR Methods
   
   MS Methods
   NMR Methods
   
   
5. Reaction Optimization Using Spectrophotometric and Other Methods
   
   Qualitative Analysis of Amines
   Quantitative Analysis of Amines
   Quantitative Spectroscopic Methods for Organic Functional Groups
   Combustion Elemental Analysis Methods
   Electrochemical Methods
   On-Resin X-ray, EPR, and Fluorescence Methods
   
   
6. Quality Control Of Combinatorial Libraries
   
   Analysis of Discrete Compound Libraries
   Analysis of Pooled Libraries
   HPLC for Analyzing Compounds from Discrete and Mixture Libraries
   
   
7. Selection of Active Compounds from Combinatorial Libraries
   
   In-solution Screening of Combinatorial Libraries
   Affinity Selection of Lead Compounds by Mass Spectrometry
   Affinity Capillary Electrophoresis
   Affinity NMR
   Other Affinity Selection Methods
   Encoding Methods
   
   
8. Optimization of Lead Compounds
   
   Lead Compounds and Lead Optimization
   Optimizing the In Vitro Activity: SAR by NMR
   Optimizing Physiochemical Properties
   
   
9. Final Thoughts and Future Perspectives
   
   Reaction Optimization Efforts
   Miniaturized Analysis
   Parallel Analysis
   HT NMR Data Interpretation
   LC-NMR-MS

Appendices
Index

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