Anemia of Chronic Disease summarizes the most current research on the anemia of chronic disease and identifies effective diagnostic strategies.

Features:

• Gives a broad overview of currently available treatment methods and their advantages/disadvantages in regards to ACD
• Offers a critical discussion of well-established and emerging diagnostic tests in ACD diagnosis
• Studies the role of new regulator molecules in ACD
• Provides a timely overview of relevant information on iron metabolism, the function of erythropoietin, and the immunopathology of inflammation
• Surveys controversies in ACD therapy

Contents

• Anemia of Chronic Disease: The Enigma and the Challenge
• Basic Regulation of Iron Metabolism
• Erythropoietin and Erythropoiesis
• The Systemic Inflammatory Response
• Pathophysiology
• Disturbance of Iron Homeostasis: Iron Limited Erythropoiesis
• Inhibition of Erythroid Progenitor Cell Proliferation
• Blunted Response to Erythropoetin/Insufficient Erythropoeitin Synthesis
• Erythrophagocytosis, Decreased Erythrocyte Survival
• New Regulator Molecules in ACD
• ACD-Rational: Is Anemia Part of the Body's Physiological Response To Inflammation
• Iron Withholding as a Defense Strategy
• Iron and Immunity
• Diagnosis of ACD
• Clinical Approach to the Patient with ACD
• Usefulness of Old and New Diagnostic Tests in ACD
• Therapy
• Introduction of ACD Therapy
• Human Recombinant Erythropoeitin Iron
• Blood Transfusions
• Future Approaches: Iron and Erythropoietin
• Controversies in ACD Therapy
• Putative Positive Effects of ACD Correction
• Putative Negative Effects of ACD Correction in Malignant and Infectious Diseases
• Specific Conditions of ACD
• ACD in Hematolgical Disorders and Cancer
• Anemia in Cancer Patients Undergoing Surgery
• ACD in Systemic Infections Including HIV
• ACD in Rheumatic and Autoimmune Disorders
• Anemia in Intensive Care Patients
• ACD as Part of Chronic Renal Disease
• ACD in Inflammatory Bowel Disease

Index

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