Animal Models of Cognitive Impairment provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction.

Features:

• Integrates molecular and neurochemical approaches to behavioral application in translational animal models and clinical applications
• Features cutting-edge research on genetic, lesion, pharmacological toxicant, and aging models
• Includes contributions from distinguished active researchers in the field of cognitive therapy research

Contents

Pharmacologic Models

• Muscarinic Receptor Antagonists in Rats
• Nicotinic Receptor Antagonists in Rats
• Involvement of the NMDA System in Learning and Memory
• Animal Models and the Cognitive Effects of Ethanol

Toxicologic Models

• Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure
• Developmental Behavioral Toxicity of Methylmercury: Consequences, Conditioning, and Cortex
• Executive Function Following Developmental Exposure to Polychlorinated Biphenyls (PCBs): What Animal Models Have Told Us
• Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey

Mouse Genetic Models

• Cognitive Impairment in Transgenic Mouse Models of Amyloid Deposition
• Cholinergic Receptor Knockout Mice
• Assessments of Cognitive Deficits in Mutant Mice

Model Applications and Future Developments

• Cognitive Pharmacology in Aging Macaques
• Cognitive Impairment following Traumatic Brain Injury
• Cognitive Impairment Models Using Complementary Species
• Cognition Models and Drug Discovery

Index

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