This volume summarizes current understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complication. Presenting results of studies aimed at regulating oxidatively induced complications through the use of antioxidants.

Antioxidants in Diabetes Management also examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications, stimulating scientific discussion and curiosity about the causes of diabetes.

With contributions from nearly 65 clinicians and researchers who cite more than 1300 sources, Antioxidants in Diabetes Management:

• focuses on stringent control of hyperglycemia to prevent or modify onset and progression
• promotes the development of intervention strategies because of the therapeutic limitations of hypoglycemic therapy
• emphasizes the potential synergistic effects of an interlinked antioxidant network
• investigates the controversy surrounding the significance of oxidative stress markers in diabetes
• highlights oxidative stress and antioxidant treatment in animal models for juvenile and adult onset diabetes
• explores the hypothesis that ischemic reperfusion is the primary cause of diabetic polyneuropathy
• links protein kinase C activation to the development of diabetic vascular complications and the effectiveness of vitamin E in preventing these abnormalities
• spotlights recent clinical trials of therapeutic effects of antioxidants to reduce insulin resistance
• and much more!

Illustrating the therapeutic potential of antioxidants for the treatment of diabetes, Antioxidants in Diabetes Management is an unparalleled reference for endocrinologists, nutritionists and dietitians, cell biologists and biochemists, cardiologists, pathologists, and graduate and medical school students in these disciplines.

Contents

1. Oxidative Stress and Antioxidants: The Antioxidant Network, -Lipoic Acid, and Diabetes
2. Oxidative Stress in Diabetes: Why Does Hyperglycemia Induce the Formation of Reactive Oxygen Species?
3. Oxidative Stress Markers in Human Disease: Application to Diabetes and to Evaluation of the Effects of Antioxidants
4. Plasma Lipid Hydroperoxide and Vitamin E Profiles in Patients with Diabetes Mellitus
5. Concentrations of Antioxidative Vitamins in Plasma and LDL of Diabetic Patients
6. Oxidative Stress in Diabetes
7. Antioxidative Defense in Diabetic Peripheral Nerve: Effects of DL--Lipoic Acid, Aldose Reductase Inhibitor and Sorbitol Dehydrogenase Inhibitor
8. Pathways of Glucose-Mediated Oxidative Stress in Diabetic Neuropathy
9. Experimental Diabetic Neuropathy: Oxidative Stress and Antioxidant Therapy
10. Antioxidants in the Treatment of Diabetic Polyneuropathy: Synergy with Essential Fatty Acids
11. A Thioctic Acid-Gamma-Linolenic Acid Conjugate Protects Neurotrophic Support in Experimental Diabetic Neuropathy
12. Clinical Trials of -Lipoic Acid in Diabetic Polyneuropathy and Cardiac Autonomic Neuropathy
13. Oxidative Stress, NF-kB Activation, and Late Diabetic Complications
14. Molecular Basis of -Tocopherol Action and Its Protective Role Against Diabetic Complications
15. Protein Kinase C Activation, the Development of Diabetic Vascular Complications, and the Role of Vitamin E in Preventing These Abnormalities
16. Oxidative Stress and Pancreatic -Cell Destruction in Insulin-Dependent Diabetes Mellitus
17. Interrelationship Between Oxidative Stress and Insulin Resistance
18. Oxidative Stress and Antixodant Treatment: Effects on Muscle Glucose Transport in Animal Models of Type 1 and Type 2 Diabetes
19. Oxidative Stress and Insulin Action: A Role for Antioxidants?

Index

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