Applied Pharmacokinetics and Pharmacodynamics places emphasis on the relationship between pharmacokinetics and pharmacodynamics.
Applied Pharmacokinetics and Pharmacodynamics is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy.
Applied Pharmacokinetics and Pharmacodynamics includes case studies that apply concepts to actual patient problems.
New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods.
Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.
Contents:
- General principles of clinical pharmacokinetics
- Guidelines for collection and analysis of pharmacokinetic data
- Critical evaluation of methods for therapeutic drug monitoring
- Analysis of pharmacokinetic data for individualizing drug dosage regimens
- Pharmacodynamics
- Influence of protein binding and use of unbound (free) drug concentrations
- Drug metabolism, transport, and the influence of hepatic disease
- Application of pharmacogenetic principles to clinical pharmacology
- Influence of renal function and dialysis on drug disposition
- Special pharmacokinetic and pharmacodynamic considerations in children
- Special pharmacokinetic considerations in the obese
- Dietary influences on drug disposition
- Asthma management
- Aminoglycosides
- Vancomycin
- Microbiologic, clinical, and economic outcomes of dual individualized dosing of antimicrobial agents
- Antivirals for HIV
- Digoxin
- Clinical pharmacokinetics of oral antiarrhythmic drugs
- Phenytoin
- Antiepileptic drugs
- Cyclosporine
- Tacrolimus
- Mycophenolic acid
- Sirolimus
- Anticancer agents
- Heparin - UFH and LMWH
- Warfarin
- Nonsteroidal anti-inflammatory drugs and coxibs
- Cyclic antidepressants
- Lithium
- Antipsychotics
Appendix - A critical assessment of the outcomes of therapeutic drug monitoring
Index
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