Atherothrombosis and Coronary Artery Disease provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume.

Coverage begins with a review of risk factors and prevention, emphasising lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included. Features:

• Includes coverage of risk factors and prevention; emphasizing lipid abnormalities, hypertension, smoking, diabetes and obesity
• Examines the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina and noncoronary atherothrombosis
• Includes clinical presentations, medical management and the latest interventional strategies

New to this second edition:

• More clinically oriented
• Trimmed to one manageable volume
• Includes only the basic science that is clinically relevant

Partial Contents

1. A Historical Perspective on Atherothrombosis and Coronary Artery Disease
2. Incidence, Prevalence, and Mortality of Coronary Artery Disease

Major Risk Factors and Primary Prevention

3. Overview

Lipid Abnormalities

4. Lipids, Nutrition, and Coronary Heart Disease
5. Genetic Dyslipoproteinemias - H. Brian Brewer, Jr. and Silvia Santamarian
6. Structure and Function of the Plasma Lipoproteins and Their Receptors
7. Plasma High Density Lipoproteins and Atherogenesis
8. Oxidized Lipoproteins and Atherosclerosis
9. Lipoprotein
10. Clinical Classifications
11. Management and ATP III Guidelines
12. Impact of Management in Stabilization and Decrease in Cardiovascular Events

Hypertension, Cigarette Smoking, Diabetes, Obesity and Others

13. Genetics and Mechanisms of Hypertension
14. Renin Angiotensin System and Atherothrombotic Vascular Disease
15. Clinical Classifications of Hypertension
16. Management of Hypertension
17. Hypertensive Heart Disease
18. Cigarette Smoking and Atherothrombosis
19. Diabetes, Obesity, and the Metabolic Syndrome
20. Hormonal Replacement: Pros and Cons
21. Vitamins: Pros and Cons

Pathogenesis of Atherosclerosis

General Principles

22. Developmental Biology of the Vasculature
23. Vasculogenesis
24. Embryogenesis of the Vascular System
25. Mouse Models of Lipoprotein and Atherothrombosis
26. Genetics of Atherothrombotic Disease

The Normal Artery

27. Vascular Endothelium
28. Role of Alterations in the Differentiated State of Smooth Muscle Cell in Atherothrombogenesis
29. The Vascular Extracellular Matrix

The Lesions of Atherothrombosis

30. The Histologic Classification of Atherosclerotic Lesions
31. Pathogenesis of Atherothrombosis
32. Atherothrombosis in Youth
33. Coronary Thrombosis—Local and Systemic Factors

Remaining sections:

Markers and Evolving Imaging of Atherothrombotic Disease
Acute Coronary Syndromes
Chronic Stable Angina
Noncoronary Atherothrombosis

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