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Cancer Therapy Book from C.H.I.P.S.

Beyond Apoptosis
Cellular Outcomes of Cancer Therapy
edited by Igor B. Roninson

Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents.

Beyond Apoptosis's goal is to examine the relative contribution of apoptosis, and to acquaint the readers with new concepts in non-apoptotic cell death, senescence, and mitotic catastrophe.

Contents

  1. A Personal History of the Development of the Apoptosis Concept
  2. What do the Clinical Data Tell Us About the Role of Apoptosis in Sensitivity to Cancer Therapy?
  3. Response of Solid Tumors to Cancer Therapy: How Relevant is Apoptosis?
  4. Historical Studies of Various Forms of Cell Death
  5. Toward a Mechanistic Taxonomy for Programmed Cell Death Pathways
  6. Caspase-Independent Apoptotic Cell Death
  7. Autophagic Cell Death in Mammalian Cells
  8. The Cellular Decision Between Apoptosis and Autophagy
  9. Parthanatos: PARP- and AIF-Dependent Programmed Cell Death
  10. Paraptosis
  11. Cellular Senescence and Its Effects on Carcinogenesis
  12. Tumor Suppressing Activities of Senescent Keratinocytes
  13. Senescence Induced by Repression of Human Papillomavirus Oncogenes in Cervical Cancer Cells
  14. Treatment-Induced Tumor Cell Senescence and Its Consequences
  15. Senescence Regulation in Cancer Therapy
  16. Exploiting Drug-Induced Senescence in Transgenic Mouse Models
  17. Therapy-Induced Cellular Senescence: Clinical Relevance, Implications, and Applications
  18. Mitotic Catastrophe in Cancer Therapy
  19. How Do Cells Die After Irradiation? Time-Lapse Studies of Cells in Culture
  20. Modes of Cell Death by Anticancer Agents: The Crucial Importance of Dose

Index

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Beyond Apoptosis
Cellular Outcomes of Cancer Therapy
edited by Igor B. Roninson

2008 352 pages $228.98 + shipping
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