This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake—offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.

Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!

Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems

• Discusses mechanical and chemical bonding, polymer–mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology
• Analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces
• Covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell–cell interactions
• Examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles
• Describes vaginal, nasal, buccal, ocular, and transdermal drug delivery
• Reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts
• Explores issues of product development, clinical testing, and production
• And much more!

Amply referenced with over 1,400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Contents

1. Fundamentals of Bioadhesion
   • Definitions, Mechanisms, and Theories of Bioadhesion
   • The Role of Water Movement and Polymer Hydration in Mucoadhesion
   • A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels
   • Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina
   • Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins
   • Bioadhesive Properties of Microspheres
   • Novel Magnetic Technique to Measure Bioadhesion
   • Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems
   • Force Microscopy of Cells to Measure Bioadhesion
   • Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems
   • A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction

2. Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems
   • Multifunctional Polymers for the Peroral Delivery of Peptide Drugs
   • Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia
   • Plant Lectins for Oral Drug Delivery to Different Parts of the Gastrointestinal Tract
   • Bacterial Invasion Factors and Lectins as Second-Generation Bioadhesives
   • Novel PEG-Containing Acrylate Copolymers with Improved Mucoadhesive Properties
   • Bioadhesive, Bioerodible Polymers for Increased Intestinal Uptake

3. Development Issues of Bioadhesive Drug Delivery Systems: Products and Clinical Trials
   • Novel Formulation Approaches to Oral Mucoadhesive Drug Delivery Systems
   • Bioadhesive Formulations for Nasal Peptide Delivery
   • Development of Bioadhesive Buccal Patches
   • Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations
   • Ocular Bioadhesive Drug Delivery Systems
   • Bioadhesive Preparations as Topical Dosage Forms

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