Biodefense presents a thorough historical and current review of biodefense research, encouraging researchers to leverage relevant results.

Features:

• Provides comprehensive information on the current methods and results of research utilizing animal models
• Compares and contrasts the use of various species for each agent and how each species can be best utilized
• Saves vital time and money, and minimizes the use of animals by presenting documented findings that can be built upon
• Presents pertinent agent information including history, identification techniques, and biochemical properties
• Explores how agent pathogenesis in animals would translate to humans
• Discusses the new FDA Animal Efficacy rule
• Covers infectious disease aerobiology and aerosol challenge methods

Contents

• The History of Biological Weapons
• Bioterrorism and Biowarfare: Similarities and Differences
• Scientific and Ethical Importance of Animal Models in Biodefense Research
• Development and Validation of Animal Models
• Infectious Disease Aerobiology: Aerosol Challenge Methods
• Anthrax
• Glanders
• Plague
• Tularemia
• Q Fever
• Alphaviruses
• Orthopoxviruses
• Viral Hemorrhagic Fevers
• Botulinum Toxins: Stephen B. Greenbaum
• Ricin: Stephen B. Greenbaum
• Staphylococcal and Streptococcal Superantigens

Index

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