by J.E. Ellingsen
and S.P. Lyngstadaas

• Describes the state-of-the-art in our understanding of the interface between implants and tissue
• Presents chapters contributed by a stellar panel of scientists from leading academic and research institutions around the world
• Provides a unique and important focus on the biological information in the interface that directs cells along advantageous pathways
• Includes a section that explores the potential of advances on the horizons of current research
• Incorporates more than 175 illustrations--some in full color

Bioimplant Interface: Improving Biomaterials and Tissue Reactions brings together a remarkable panel of scientists to present the state-of-the-art in our understanding of interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface's topography and chemistry to its interaction with the biological environment. Biomineralization along with the biological content of the interface and its role in directing cellular response along desired pathways also receive particular attention.

The pursuit of new and better designs for improved biocompatibility and patient response to implants continues to challenge clinicians and scientists alike. This book offers a unique opportunity to bring yourself up-to-date on recent advances in the field and new strategies for controlling the bio-implant interface.

Contents

1. SUCCESS AND FAILURE FOR BONE-IMPLANT ATTACHMENTS: AN EVIDENCE-BASED APPROACH
   • The Role of Implant Surface Properties on the Clinical Outcome of Osseointegrated Oral Implant Therapy

2. CAN THE IMPLANT MACRO DESIGN AND MICRO TEXTURING IMPROVE BONE RESPONSE?
   • Toward an Optimized Dental Implant Design
   • Implant Surface Design for Development and Maintenance of Osseointegration
   • Bone Response to Surface Roughness; Measurement and Results, Experiment and Clinical Studies
   • From Microroughness to Resorbable Bioactive Coatings

3. CELL AND TISSUE REACTIONS TO BIOMATERIALS
   • Improving the Bio-Implant Interface by Controlling Cell Behavior Using Surface Topography
   • Osteoblast Response to Pure Titanium and Titanium Alloy
   • Biomedical Implant Surface Topography and its Effects on Osteoblast Differentiation in vitro
   • Cellular Interactions at Commercially Pure Titanium Implants
   • A Selection of Oral Implant Materials Based on Experimental Studies
   • Possibilities to Improving Implants and Regenerating Dentoalveolar Tissues by Tissue Engineering Using Stem Cells and Growth Factors
   • Critical Issues in Endosseous Peri-Implant Wound Healing

4. THE EXTRACELLULAR MATRIX BIOLOGY AND BIOMINERALIZATION IN BONE FORMATION AND IMPLANT INTEGRATION
   • Initiation and Modulation of Crystal Growth in the Skeletal Tissues: Role of the Extracellular Matrix
   • Use of a Matrix Scaffold for Tissue Engineering and Bone Regeneration
   • Inducing Bone Growth Using Extracellular Matrix Proteins

5. SURFACE CHEMISTRY, BIOCHEMISTRY, AND MOLECULES: HOW DO THEY INTERACT WITH BIOLOGICAL ENVIRONMENT?
   • How Surfaces Interact with the Biological Environment
   • Osteocapacities of Calcium Phosphate Ceramics
   • Increasing Biocompatibility by Chemical Modification of Titanium Surfaces
   • Use of Molecular Assembly Techniques for Tailoring Chemical Properties of Smooth and Rough Titanium Surfaces

6. DEVELOPMENT AND APPLICATION OF SCIENTIFIC DATA: REGULATORY AND COMMERCIAL ASPECTS
   • Development and Application of Scientific Data: Do Industry and Academia Have Different Scientific Perspectives?
   • Medical Devices--Regulatory Perspectives and Aspects of Regulatory Risk Management

7. INVENTIVE FORWARD LOOKS-WHERE DO WE GO FROM HERE?
   • Self-Assembling and Bimimetic Biomaterials
   • The Inert-Bioactivity Conundrum
   • Enhancing the Process of Discovery and Innovation for Optimal Host Response at the Implant Surfaces

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