Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins
Third Edition
edited by Andreas D. Baxevanis

This reference provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms.

Features:

• New chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification
• Detailed worked examples illustrating the strategic use of the concepts presented in each chapter, along with a collection of expanded, more rigorous problem sets suitable for classroom use
• Special topic boxes and appendices highlighting experimental strategies and advanced concepts
• Annotated reference lists, comprehensive lists of relevant Web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics

Using relevant biological examples, Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides background on and strategies for using many of the most powerful and commonly used computational approaches for biological discovery.

This Third Edition reinforces key concepts that have stood the test of time while making the reader aware of new and important developments in this fast-moving field. With a new full-color and enlarged page design, Bioinformatics, Third Edition offers the most readable, up-to-date, and thorough introduction to the field.

Contents

Part 1: Biological Databases

1. Sequence Databases
2. Mapping Databases
3. Information Retrieval from Biological Databases
4. Genomic Databases

Part 2: Analysis at the Nucleotide Level

5. Predictive Methods Using DNA Sequences
6. Predictive Methods Using RNA Sequences
7. Sequence Polymorphisms

Part 3: Analysis at the Protein Level

8. Predictive Methods Using Protein Sequences
9. Protein Structure Prediction and Analysis
10. Intermolecular Interactions and Biological Pathways

Part 4: Inferring Relationships

11. Assessing Pairwise Sequence Similarity: BLAST and FASTA
12. Creation and Analysis of Protein Multiple Sequence Alignments
13. Sequence Assembly and Finishing Methods
14. Phylogenetic Analysis
15. Computational Approaches in Comparative Genomics
16. Using DNA Microarrays to Assay Gene Expression
17. Proteomics and Protein Identification

Part 5: Developing Tools

18. Using Perl to Facilitate Biological Analysis

Appendices
Glossary
Index

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