Bioorganometallics is an excellent source of high quality information for experts in the field.

Features:

• Details the history of bioorganometallics
• Covers pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals

Contents

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

• Organometallics and Therapy
• Toxicology and the Environment
• Bioanalytical Methods Based on Special Properties of Organometallic Complexes
• Naturally-occurring Organometallics and Synthetic Models
• Organometallic Chemistry and Aqueous Solvents

Ruthenium Arene Anticancer Complexes

• Metal-based Anticancer Complexes
• Chemistry of Ru Arenes
• Biological Activity
• Mechanism of Action

Organometallics Targeted to Specific Biological Sites: the Development of New Therapies

• Overview of Previous Developments
• Metal Complex SERMs (Selective Estrogen Receptor Modulators)
• The Alkyne Cobalt Carbonyl Complexes
• Ferroquine, a New Weapon in the Fight Against Malaria: the Archetypical Bioorganometallic Approach
• Other Examples of Organometallics Complexes Tested for their Biological Activities

Radiopharmaceuticals

• What are Radiopharmaceuticals
• Organometallic Aquo-ions
• The Prototype [99Tc(OH2)3(CO)3]+, Synthesis and Properties
• Combining [99Tc(OH2)3(CO)3]+ with Targeting Vectors

Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications

• Conjugates of Organometallics with Small Peptides
• Conjugates of Organometallics with Natural Peptides
• Conjugates of Organometallics with PNA

Labeling of Proteins with Organometallic Complexes: Strategies and Applications

• Redox Probes
• Luminescent Probes
• Heavy Metal Probes
• Metallo–carbonyl Probes for Infrared Spectroscopy

Organometallic Bioprobes

• The Definition of the Terms Bioprobes and Molecular Bioprobes
• Response Strategies for the Read-out of Information
• Organometallic Components for Organometallic Bioprobes – Opening up the Advantages of IR-based Read-out Methods
• Selectivity of Responses in IR-based Read-out Methods
• Examples of Organometalcarbonyl Bioprobe Structures
• Use of Organometallic Bioprobes with Proteins
• Power of Genetics in the Design of Bioprobe Experiments

Organometallic Complexes as Tracers in Non-isotopic Immunoassay

• Principle of an Immunoassay
• Obtaining Specific Antibodies
• Synthesis of the Organometallic Tracers
• Examples of Mono- and Multi-metalloimmunoassays (MIA)
• Use of Organometallic Complexes as Substrates or Co-substrates for Enzyme Immunoassay

Genosensors Based on Metal Complexes

• Metal Complexes as DNA Probes
• Electrochemical Analysis of the Interaction of Metal Complexes with dsDNA
• Gene Detection Based on a Cationic Metal Complex or Metal Complex Conjugated with DNA-binding Ligand
• Gene Detection Based on Ferrocenyl Oligonucleotides as a Metal Complex Conjugated with DNA Fragments

Supramolecular Host Recognition Processes with Biological Compounds, Organometallic Pharmaceuticals, and Alkali-metal Ions as Guests

• Host 1
• A New Host, trans-[Cp*Rh?1-(N3)-1-methylcytosine)(µ-OH)]2(OTf)2
• Computer Docking Experiments of Organometallic Pharmaceuticals at Estrogen Receptor Binding Sites: Selective, Non-Covalent Interactions with Hormone Proteins
• Organometallic Ionophores
• Overall Conclusions for Molecular Recognition

Structure and Mechanism of Metalloenzyme Active Sites

• Copper
• Iron
• Manganese
• Molybdenum and Tungsten
• Nickel
• Zinc

Synthetic Models for Bioorganometallic Reaction Centers

• Fe-only Hydrogenase
• NiFe Hydrogenases
• Acetyl CoA Synthase
• Anaerobic Carbon Monoxide Dehydrogenase
• Aerobic Carbon Monoxide Dehydrogenase
• Methyl Coenzyme M Reductase

Index

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