Second Edition
edited by Martin Malmsten

This new edition features research from nearly 60 of the profession’s most distinguished international authorities!

Recognizing emerging developments in biopolymer systems research with fully updated and expanded chapters, the Second Edition discusses the

• biopolymer-based multilayer structures and their application in biosensors
• the progress made in the understanding of protein behavior at the air–water interface
• experimental findings in ellipsometry and reflectometry
• recent developments concerning protein interfacial behavior in microfabricated total analysis systems and microarrays

Replete with over 3,000 references, Biopolymers at Interfaces is an essential reference for professionals and students in surface, pharmaceutical, colloid, polymer, and medicinal chemistry; chemical, formulation, and application engineering; and pharmacy.

Contents

1. Concepts
   1. Macromolecular Adsorption: A Brief Introduction
   2. Driving Forces for Protein Adsorption at Solid Surfaces
   3. Thermodynamics of Adsorption of Amino Acids, Small Peptides, and Nucleic Acid Components on Silica Adsorbents
   4. Quantitative Modeling of Protein Adsorption
   5. Interfacial Behavior of Protein Mutants and Variants
   6. Orientation and Activity of Immobilized Antibodies
   7. Interactions Between Surfaces Coated with Carbohydrates, Glycolipids, and Glycoproteins
   8. Protein Adsorption Kinetics
   9. Mobility of Biomolecules at Interfaces
   10. Protein Adsorption in Relation to Solution Association and Aggregation
   11. Mechanism of Interfacial Exchange Phenomena for Proteins Adsorbed at Solid—Liquid Interfaces
   12. Interactions Between Proteins and Surfactants at Solid Surfaces
   13. Toward Functionalized Polyelectrolyte Biofilms
   14. Self-Assembly of Functional Protein Multilayers: From Planar Films to Microtemplate Encapsulation
   15. Biological Activity of Adsorbed Proteins
   16. Protein Interactions with Monolayers at the Air–Water Interface

2. Methods
   17. Local and Global Optical Spectroscopic Probes of Adsorbed Proteins
   18. Proteins on Surfaces: Methodologies for Surface Preparation and Engineering Protein Function
   19. Studies on the Conformation of Adsorbed Proteins with the Use of Nanoparticle Technology
   20. Scanning Calorimetry in Probing the Structural Stability of Proteins at Interfaces
   21. Ellipsometry and Reflectometry for Studying Protein Adsorption
   22. Surface Plasmon Resonance Spectroscopies for Protein Binding Studies at Functionalized Surfaces
   23. Neutron Reflection Study of Protein Adsorption at the Solid-Solution Interface
   24. XPS, ToF-SIMS, and MALDI-MS for Characterizing Adsorbed Protein Films

3. Applications
   25. Interactions of Proteins with Polymeric Synthetic Membranes
   26. Protein Adsorption in Intravenous Drug Delivery
   27. Control of Protein Adsorption in Solid-Phase Diagnostics and Therapeutics
   28. Protein Interfacial Behavior in Microfabricated Analysis Systems and Microarrays
   29. Protein Adsorption in the Oral Environment
   30. Adsorbed Biopolymers: Behavior in Food Applications

Index

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