Cholesterol-Lowering Therapy
Evaluation of Clinical Trial Evidence

edited by Scott Grundy

This book reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States.

This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD).

The studies presented in this book promote cholesterol reduction as a highly successful means of preventing heart disease in various populations.

It investigates past, current, and upcoming controlled clinical trials of cholesterol-reduction therapies, comparing effects of statins and bile acid sequestrants to triglyceride-lowering drugs and antioxidants.

Features

• Highlights historical studies of dietary trials designed to reduce CHD
• Covers tests of HMG CoA reductase inhibitors for patients with and without CHD
• Illuminates CHD risk factors such as diabetes, hypertension, obesity, and smoking
• Explores blood levels of homocysteine and lipoprotein(a) and other recently identified CHD risk factors
• Reviews metabolism of lipoproteins expressed in high (HDL) and low (LDL) density lipoprotein cholesterol
• And more!

Containing over 700 instructive tables, drawings, photographs, and bibliographic citations, Cholesterol-Lowering Therapy is a must-read resource for cardiologists, pharmacologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Contents

1. Cholesterol-Lowering Clinical Trials: A Historical Perspective
2. Scandinavian Simvastatin Survival Study (4S)
3. Cholesterol and Recurrent Events Trial (CARE): The Effect of Pravastatin on Coronary Events After Myocardial Infarction in Patients with Average Cholesterol Levels
4. Lessons from the West of Scotland Coronary Prevention Study (WOSCOPS)
5. Program on the Surgical Control of the Hyperlipidemias (POSCH) Trial: A Pivotal 25-Year Study
6. Air Force/Texas Atherosclerosis Prevention Study (AFCAPS/TexCAPS): Primary Prevention of Acute Major Coronary Events in Women and Men with Average Cholesterol
7. Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study: Clinical Implications for Cardiovascular Practice
8. Angiographic Results of Lipid-Lowering Trials: A Systematic Review and Meta-Analysis
9. Biochemical Correlates of Plaque Progression and Coronary Events
10. Lipid Therapy to Stabilize the Vulnerable Atherosclerotic Plaque: New Insights into the Prevention of Cardiovascular Events
11. Cholesterol-Lowering Trials with Carotid Ultrasonographic Outcomes
12. Cholesterol Lowering Reduces Mortality: The Statins

Index

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