The spectacular progress in developmental neurobiology, the dramatic advances in (neuro)genetics and the high resolution of the modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS).

Clinical Neuroembryology provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders due to genetic, environmental and hypoxic causes.

Clinical Neuroembryology is unique in the combination of data from human embryology, animal research and developmental neuropathology.

Contents

1. Overview of the Development of the Human Brain and Spinal Cord

• Major Stages in the Development of the Human Brain and Spinal Cord
• The First 3 Weeks of Development
• Neurulation
• Development of the Spinal Cord
• Pattern Formation of the Brain
• Early Development of the Brain
• Fetal Development of the Brain
• Development of the Meninges and Choroid Plexuses
• Development of the Blood Supply of the Brain
• Development of Fibre Tracts (Including Development of Myelination)

2. Mechanisms of Development

• Neural Induction
• Cell Lineage Studies and Fate Mapping
• Pattern Formation
• Neurogenesis, Gliogenesis and Migration
• Axon Outgrowth and Guidance
• Programmed Cell Death

3. Causes of Congenital Malformations

• Causes of Congenital Malformation
• Inborn Errors of Metabolism Affecting the CNS
• Myelination Disorders
• Vascular Disorders
• Classifications of CNS Malformations

4. Neurulation and Neural Tube Defects

• Primary Neurulation
• Secondary Neurulation
• Genetic Mouse Models for Neural Tube Defects
• Aetiolog of Human Neural Tube Defects
• Prenatal Diagnosis
• Cranial Neural Tube Defects
• Spinal Neural Tube Defects
• The Chiari Malformations
• Caudal Dysgenesis

5. The Neural Crest and Craniofacial Malformations

• Induction of the Neural Crest
• Derivatives of the Neural Crest
• Craniofacial Development
• Neurocristopathies
• Holoprosencephaly
• Abnormal Development of the Skull with CNS Manifestations

6. Development and Developmental Disorders of the Spinal Cord

• Gross Development of the Spinal Cord
• Developmental Events in Spinal Neuronal Populations
• The Specification of Cell Fates in the Spinal Cord
• Development of Dorsal Root Projections
• Development of Spinal Ascending Projections
• Development of Descending Projections to the Spinal Cord
• Developmental Anomalies of the Spinal Cord

7. Development and Developmental Disorders of the Brain Stem

• Pattern Formation and Segmentation of the Brain Stem
• Development and Developmental Disorders of the Cranial Nerves
• Development of the Auditory System

8. Development and Developmental Disorders of the Human Cerebellum

• Some Notes on the Anatomy of the Cerebellum
• Morphogenesis of the Cerebellum
• Four Basic Steps in the Histogenesis of the Cerebellum
• Development of the Precerebellar Nuclei
• Mouse Mutants with Cerebellar Malformation
• Developmental Disorders of the Cerebellum

9. Development and Developmental Disorders of the Forebrain

• Prosomeres and Pattern Formation of the Forebrain
• Development of the Diencephalon
• Development of the Visual System
• Overview of the Development of the Telencephalon
• Development of the Rhinencephalon
• The Prosencephalies
• Development and Developmental Disorders of the Bsal Ganglia and the Amygdala

10. Development and Developmental Disorders of the Cerebral Cortex

• Overview of the Cerebral Cortex
• Overview of Main Cortical Connections
• Development of the Neocortex
• Development of the Hippocampal Formation
• Development of the Main Cortical Connections
• Developmental Disorders of the Cerebral Cortex

Index

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