Computational Methods for Mass Spectrometry Proteomics describes the different instruments and methodologies used in proteomics in a unified manner.

The book is illustrated by a number of figures and examples, and contains exercises for the reader.

Computational Methods for Mass Spectrometry Proteomics is suited for advanced undergraduate and graduate students of bioinformatics and molecular biology with an interest in proteomics.

Contents

1. Protein, Proteome, and Proteomics
2. Protein Separation - 2D Gel Electrophoresis
3. Protein Digestion
4. Peptide Separation - HPLC
5. Fundamentals of Mass Spectrometry
6. Mass Spectrometry - MALDI-TOF
7. Protein Identification and Characterization by MS
8. Tandem MS or MS/MS Analysis
9. Fragmentation Models
10. Identification and Characterization by MS/MS
11. Spectral Comparisons
12. Sequencial Comparison - de novo Sequencing
13. Database Searching for De Novo Sequences
14. Large-Scale Proteomics
15. Quantitative Mass Spectrometry-Based Proteomics
16. Peptides to Proteins
17. Top-Down Proteomics
18. Standards

Index

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