Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery.

Features:

• Highlights new developments in the area of synthetic, organic, and combinatorial chemistry
• Describes and analyzes strategies and designs for the successful synthesis of libraries
• Includes examples of natural product-based libraries that illustrate how libraries are designed to achieve desired biological properties
• Highlights the role of bioinformatics in analyzing properties and behavior of compound libraries
• Examines how to improve efficiency of combinatorial screening
• Offers 280 figures and schemes for visualizing concepts more clearly, as well as comprehensive references to recently published primary and review literature

Contents

1. Chemistry on the Interface of Natural Products and Combinatorial Chemistry
2. Natural Products and Combinatorial Chemistry - An Uneasy Past but a Glorious Future
3. Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product-Based Compound Libraries
4. Accessing Expanded Molecular Diversity through Engineered Biosynthesis of Natural Products
5. Natural Product-Based, Chemically and Functionally Diverse Libraries
6. The Use of Polymer-Supported Reagents and Scavengers in the Synthesis of Natural Products
7. Carbohydrate-Derived Small-Molecule Libraries
8. In Search of Novel Antibiotics Using a Natural Product Template Approach
9. Synthetic Libraries of Fungal Natural Products
10. Solid-Phase Combinatorial Synthesis Based on Natural Products
11. Employing Natural Product-Like Combinatorial Libraries in the Discovery of Lead Libraries

Index

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