Control and Regulation of Transport Phenomena in the Cardiac System have contributed chapters that identify, analyze, and modify the control and regulation mechanisms of transport phenomena in biological systems, with particular emphasis on the cardiac system.

Control and Regulation of Transport Phenomena in the Cardiac System features:

• signaling mechanisms and transport phenomena
• blood-tissue exchange and inter-tissue transport
• cellular membrane transport and endocytosis of ions and metabolites
• intracellular transport, energetics, and molecular motors
• system biology, uni- and multi-scale transport models, and hierarchical analysis

Contents

1. Signaling Pathways and Transport Phenomena

1. The Death of Transcriptional Chauvinism in the Control and Regulation of Cardiac Contractility
2. Genetic Mechanisms Controlling Cardiovascular Development
3. MicroRNAs Control Gene Expression: Importance for Cardiac Development and Pathophysiology
4. Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair: Developmental Role of Periostin

2. Intra-cellular Transport and Energetics

5. The Missing Link in the Mystery of Normal Automaticity of Cardiac Pacemaker Cells
6. Shear Fluid Induced Ca2+ Release and the Role of Mitochondria in Rat Cardiac Myocytes
7. Cardiac Cell Hypertrophy in vitro
8. The Role of Ca2+ in Coupling Cardiac Metabolism with Regulation of Contraction. in Silico Model
9. Sarcomere Mechanics in Uniform and Nonuniform Cardiac Muscle

3. Ions and Metabolites Membrane Transport

10. Modulation of Cardiac Performance by Motor Protein Gene Transfer
11. Atrial-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation
12. Molecular Basis of Cardiac Action Potential Repolarization
13. Intracellular Transport

4. Inter-tissue Transport

14. Linking Cellular Energetics to Local Flow Regulation in the Heart
15. Regulation of Endothelial Junctional Permeability
16. Controlling Cardiac Transport and Plaque Formation

5. Transport Models and Hierarchical Analysis

17. Multiscale and Modular Analysis of Cardiac Energy Metabolism
18. Discovering Regulators of the Drosophila Cardiac Hypoxia Response using Automated Phenotyping Technology
19. Multi-scale Model of 02 Transport and Metabolism

6. Clinical Aspects

20. Mapping Preconditioning’s Signaling Pathways
21. The Identity and Regulation of the Mitochondrial Permeability Transition Pore
22. Control of Cardiac Rate by “Funny” Channels in Health and Disease
23. Experimental Molecular and Stem Cells Therapies in Cardiac Electrophysiology
24. Controlling Ischemic Cardiovascular Disease

Index

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