Cryopreservation: Applications in Pharmaceuticals and Biotechnology provides a foundational introduction to the cryopreservation of biological materials and their development into pharmaceutical products. It is a critical study based on today's requirements for rapid development of biologically derived dosage forms of drugs.

This book covers the principles of cryopreservation as they relate the preservation of viable cells and cell materials being developed for biopharmaceutical applications.

Topics include:

• the principles of freezing and thawing cells
• physiochemical phenomena
• process and system design options
• method selection considerations
• preservation procedures
• cryoprotectant additives
• freeze-drying human live virus vaccines
• transport system selection criteria

Contributions from well-known experts such as Steven S. Lee, Thomas C. Pringle, William H. Siegel, Richard Wisniewski, and Fangdong Yin make this the single most important study available.

Contents

1. Introduction
2. Principles of Large Scale Cryopreservation of Cells, Microorganisms, Protein Solutions and Biological Products
3. Large-Scale Cryopreservation: Process Development for Freezing and Thawing of Large Volumes of Cell Suspensions, Protein Solutions and Biological Products
4. Method Selection Considerations for Long-Term Preservation of Mammalian Cells and Microorganisms
5. Cryopreservation of Mammalian Cell Cultures
6. Freeze-Drying of Human Live Virus Vaccines
7. The Design and Use of Thermal Transport Containers

Index

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