Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes.

Features:

• Discusses modern statistical methods and bioinformatics resources
• Provides an up-to-date overview of modern SNP typing methodologies
• Illustrates different approaches to bioinformatics and genetic design problems
• Presents careful descriptions of studies that relate cytokine markers to diseases and their individual symptomatic presentations
• Summarizes genetic association studies on cytokine gene polymorphisms in clearly organized and accessible tables
• Contains 14 chapters dedicated to the cytokine genetics of distinct multifactorial conditions
• Includes figures that clarify aspects of cytokine biology, linkage disequilibrium patterns, and SNPs in cytokine genes

Contents

General Concepts

• The Biology of Cytokines:General Principles, Properties and Lessons from Animal Models
• Genetics of Multifactorial Disorders
• Statistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions
• Introduction to Integrated Bioinformatic Resources for Cytokine Genetics Research
• Cytokine Gene Nucleotide Sequence Alignments
• SNP Genotyping Techniques

Cytokine Gene Polymorphisms

• The IL1 Cluster
• IL-2 Biology and Polymorphisms in Multifactorial Conditions
• The Chromosome 5q23.1 -q31.1 Cluster of Cytokines
• IL10
• The IL19 Subfamily of Cytokines
• The IFNG -IL26 -IL22 Cytokine Gene Cluster
• TNF-a Polymorphisms and Disease
• Macrophage Migration Inhibitory Factor (MIF)
• Polymorphisms of Chemokines and Their Receptors

Polymorphic Cytokine Networks in Multifactorial Conditions

• Asthma and Atopy
• Common Rheumatic Diseases
• Systemic Lupus Erythematosus
• Sjögren 's Syndrome
• Multiple Sclerosis
• Type 1 and 2 Diabetes
• Psoriasis
• Diseases of the Gastrointestinal Tract
• Pulmonary Fibrosis
• Atherosclerosis
• Longevity
• AIDS
• Tropical Infectious Diseases
• Suseptibility to Infection and Severe Disease in Schistosomiasis

Index

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