• Provides an extensive overview of the available information concerning adverse postnatal consequences of perinatal immunotoxicological exposure
• Highlights different classes of developmental immunotoxicants such as halogenated and polycyclic aromatic hydrocarbons, pesticides, and heavy metals
• Discusses the spectrum of immune defects caused by immunotoxic compound exposure during development
• Describes the consequences of immune dysregulation (i.e. autoimmune and allergic disease) following developmental exposures

Despite the dramatic increased interest in this area, there is no textbook on developmental immunotoxicology. Filling the void, this book begins with overviews of immune system development in experimental animal models and human and the complex issues dealing with the evolution of developmental immunology and risk assessment. This is followed by sections describing different animal models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as it related to developmental immunotoxicology.

Contents

1. Development of the Immune System
   • Development of the Rodent Immune System
   • Development of the Human Immune System

2. Developmental Immunotoxicology: Models
   • Risk Assessment Perspectives for Developmental Immunotoxicology
   • The Mouse as a Model for Developmental Immunotoxicology
   • The Rat as a Model for Developmental Immunotoxicology
   • The Pig as a Model for Developmental Immunotoxicology
   • The Non-Human Primate as a Model for Developmental Immunotoxicology

3. Developmental Immunotoxicant Exposure and Postnatal Immunosuppression
   • Polycyclic Halogenated Hydrocarbons and Polycyclic Aromatic Hydrocarbons
   • Developmental Immunotoxicity of Chlordane
   • Toxicity of Lead to the Developing Immune System
   • Developmental Immunotoxicity of Therapeutic Agents
   • Mycotoxins and Other Miscellaneous Developmental Immunotoxicants

4. Developmental Immunotoxicant Exposure and Exacerbated Postnatal Immune Responses
   • Prenatal Immunotoxicant Exposure and Autoimmune Disease
   • Developmental Immunotoxicant Exposure and Postnatal Asthma

5. Neuroimmune Interactions
   • Developmental Neurotoxicity and Postnatal Immune Deficits
   • Impact of Gender and Negative Energetic Balance Condition on the Mechanisms of the Acute Phase Response of the Inflammatory Process in Mammals

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