A Fundamental & Clinical Text
Third Edition
by Derek LeRoth
Diabetes Mellitus encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus.
Contents
Insulin Secretion
- The Two Phases of Glucose-Stimulated Insulin Secretion: Mechanisms and Controls
- Insulin Gene Regulation
- Processing of the Insulin Molecule
- Electrophysiology of the Pancreatic B-Cell
- Sulfonylurea Receptors, Adenosine Triphosphate-Sensitive Potassium Channels, and Insulin Secretion
- Insulinotropic Glucagon-Like Peptides
- Detrimental Effects of Chronic Hyperglycemia on the Pancreatic B-Cell
- Glucose Toxicity of the B-Cell: Cellular and Molecular Mechanisms
- Lipotoxity
- Islet Amyloid in Type 2 Diabetes
Insulin Action
- Physiologic Action of Insulin
- Integration of Biomechanical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations
- Glucose Counterregulatory Hormone: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia
- The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation
- The Insulin Signaling Network and Insulin Action
- Knockout Mice as a Tool to the Understanding of Diabetes Mellitus
- Regulation of Insulin Action by Protein-Trosine Phosphatases
- Small GTPases and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction
- Protein Kinase C
- Regulation of Glycogen Synthesis
- Insulin Action on Glucose Transport
- Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation
- Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes
- Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion
- Gene Regulation
- Insulin Degradation
- Insulin and the Ras-Dependent Signaling Pathway
- Germline Manipulations of Glucose Transport and Glucose Homeostasis
- Molecular Links between Peroxisome Proliferator-Activated Receptor-y and Metabolic Disease
Definition and Classification
- Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis
Type 1 Diabetes Mellitus
- The Natural History of Autoimmunity in Type 1A Diabetes Mellitus
- Genetics of Type 1 Diabetes
- Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus
- Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus
- Major Histocompatibility Locus and Other Genes That Determine the Risk for Development of Type 1 Diabetes Mellitus
- Association between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases
- Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus
- Animal Models of Autoimmune Diabetes Mellitus
- Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes
- Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome
Therapeutics For Type 1 Diabetes Mellitus
- Application of the Diabetes Control and Complications Trial
- Diet Therapy in Type 1 Diabetes Mellitus
- Exercise for the Patient with Type 1 Diabetes Mellitus
- Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus
- Immune Intervention
- Islet Cell Transplantation
- Islet Transplantation
- Pancreas Transplantation
- Gene Therapy for Metabolic Disease
- Surrogate B-cells for Insulin Replacement Therapy
- Stem Cells
Type 2 Diabetes Mellitus
- Epidemiology of Type 2 Diabetes Mellitus
- Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus
- Noninvasive Imaging of Insulin Action and Resistance in Humans
- Genetics of Human Obesity
- Obesity: Treatment
- Obesity in Type 2 Diabetes Mellitus
- Effects of Aging on Glucose Homeostasis
- Drug-Induced Diabetes Mellitus
- Insulin Secretion in Type 2 Diabetes Mellitus
- Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome
- Glucose Transporters and Pathophysiologic States
- Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action
- Inflammation, Tumor Necrosis Factor-x, and Insulin Resistance
- Adipokines: Regulators of Metabolic Integration and Energy Metabolism
- Fatty Acids and Insulin Resistance
- Triglyceride in Muscle
- Candidate Genes for Type 2 Diabetes Mellitus
- Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipoatrophic Diabetes
- Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus
- Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus
- Primate Animal Models of Type 2 Diabetes
Therapeutics for Type 2 Diabetes Mellitus
- Preventing Type 2 Diabetes: The Diabetes Prevention Program
- Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load
- Exercise in Patients with Type 2 Diabetes Mellitus
- Insulin Secretogogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives
- Metformin
- Peroxisome Proliferator-Activated Receptor Modulators
- x-Glucosidase Inhibitors in the Treatment of Diabetes
- Glinides
- Combination Therapy in Type 2 Diabetes Mellitus
- Intensive Insulin Therapy for Patients with Type 2 Diabetes
- Hypoglycemia in Type 2 Diabetes Mellitus
- New Therapies to Promote Insulin Action
Pregnancy
- Intermediary Metabolism during Pregnancy: Implications for Diabetes Mellitus
- Effects of Maternal Diabetes Mellitus on Intrauterine Development
- Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications
- Gestational Diabetes Mellitus
Descriptive and Clinical Complications
- Pathophysiology of Diabetic Retinopathy
- Pathogenesis of Diabetic Nephropathy
- Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment
- Diabetes Mellitus, Lipids, and Atherosclerosis
- Pathophysiology of Hypertension in Diabetes Mellitus
- Macrovascular Complications of Diabetes Mellitus
- Skin and Diabetes
- Neonatal Diabetes Mellitus
- Hypoglycemia in the Adult
Mechansisms of Complications
- Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism
- Hyperinsulinemia and Insulin Resistance
- The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications
- Oxidative Stress, Inflammation, and Diabetic Complications
- Diabetic Vasculopathy
Index
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