Features of DNA Methylation:
- Discusses the impact of DNA methylation in human health and disease
- Includes concepts, experimental models, and clinical uses of demethylating agents
- Presents the most current research on the impact of DNA methylation in cancer
- Features the work of the foremost leaders in the field
DNA Methylation is a guide to understanding the complex regulatory roles of DNA methylation. It describes the relation that this biological mechanism has to gene silencing in disease and explores its promising role in treating cancer.
DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its role in treating cancer.
Contents
- Impact of DNA Methylation in Human Health and Disease
- Uses of DNA Methylation in Cancer Diagnosis and Risk Assessment
- DNA Methylation in Imprinting, X-Chromosome Inactivation and Associated Diseases
- Studying Mammalian DNA Methylation: Bisulfite Modification
- Bisulfite PCR-Based Techniques for the Study of DNA Methylation
- Microarray Analysis of DNA Methylation Targets Identified by Methyl-CpG Binding Proteins
- Methylation Arbitrarily-Primed PCR and Derived Methodologies
- Discovering DNA Methylation Differences with Restriction Landmark Genome Scanning
- Quantitative Determination of 5-methylcytosine DNA Content: HPCE and HPLC
- Qualitative Determination of 5-methylcitosine DNA and other Components of the DNA Methylation Machinery: Immunofluorescence and Chromatin Immunoprecipitation
- Mouse Models for the Study of DNA Methylation
- DNA Demethylating Agents: Concepts
- DNA Demethylating Agents: Preclinical Evaluation as Anticancer Agents
- DNA Demethylating Agents: Clinical Uses
Index
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