Features:

• Natural Products
• Chemical Synthesis
• The Use of Combinatorial Libraries
• Structural Characterization
• Contributions on Molecular Modeling
• Investigations into the way drugs interact with its nucleic acid recognition site

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids.

Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex.

In this comprehensive set, the important aspects of nucleic acid binding is described in detail, and in so doing present impressive approaches to drug design.

Contents

VOLUME 1

1. Forty Years On
2. Targeting HIV RNA with Small Molecules
3. RNA Targeting by Bleomycin
4. Inhibitors of the Tat-TAR Interactions
5. DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides
6. Salen-Metal Complexes
7. Charge Transport in DNA
8. DNA Interactions of Novel Platinum Anticancer Drugs
9. Electrochemical Detection of DNA with Small Molecules
10. Design and Studies of Abasic Site Targeting Drugs: New Strategies for Cancer Chemotherapy
11. Interactions of Macrocyclic Compounds with Nucleic Acids
12. Triplex- versus Quadruplex-specific Ligands and Telomerase Inhibition

VOLUME 2

13. Design and Analysis of G4 Recognition Compounds
14. Triple Helix-specific Ligands
15. Polyamide Dimer Stacking in the DNA Minor Groove and Recognition of T·G Mismatched Base Pairs in DNA
16. Dicationic DNA Minor Groove Binders as Antimicrobial Agents
17. Energetics of Anthracycline-DNA Interactions
18. Acridine-4-carboxamides and the Concept of Minimal DNA Intercalators
19. DNA Topoisomerase-targeted Drugs
20. Targeting DNA and Topoisomerase 1 with Indolocarbazole Antitumor Agents
21. Defining the Molecular Interactions that are Important for the Poisoning of Human Topoisomerase 1 by Benzimidazoles and Terbenzimidazoles
22. Binding and Reaction of Calicheamicin and Other Enediyne Antibiotics with DNA
23. Devising a Structural Basis for the Potent Cytotoxic Effects of Ecteinascidin 743
24. The Azinomycins Discovery, Synthesis, and DNA-binding Studies
25. The Generation and DNA-Interaction of PBD and CBI Libraries

Index

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