DNA Vaccines details in the initial chapters the immunological mechanisms that govern immune responses to vector encoded antigens.

The remaining chapters illustrate the use of DNA vaccines for prevention or therapy of infectious diseases, cancer, autoimmune reactions, allergies and rejection of proteins delivered within the realm of gene therapy.

Contents

1. Overview of Vaccinology in Historic and Future Perspective: The Whence and Whither of a Dynamic Science with Complex Dimensions
2. Dendritic Cells: Important Adjuvants During DNA Vaccination
3. Activation of the Innate Immune System by DNA Vaccines
4. Induction of B Cells by DNA Vaccines
5. Immune Responses to DNA Vaccines: Induction of CD8⁺ T Cells
6. Minigene-Based Vaccines for Eliciting CD8⁺ T Cell Responses
7. DNA Vaccines Against RNA Viruses
8. DNA Vaccines Against Herpesviruses
9. Genetic Immunization Against HIV
10. DNA Vaccines Against Bacterial Pathogens
11. DNA Vaccines as Cancer Treatment Modalities
12. DNA Vaccines for Allergic Diseases
13. Immune Responses in gene Transfer for Genetic Disorders
14. The Use of DNA Vaccines for Neonatal/Early Life Childhood Immunization
15. DNA Delivery with Attenuated Intracellular Bacteria
16. Cytokines and Immunomodulatory Ligands as Genetic Adjuvants
17. Chemokines: Role as Immunomodulators and Potential as Adjuvants for DNA Vaccines
18. DNA Vaccines: Safety and Regulatory Issues
19. The Introduction of New DNA Vaccines into Developing Countries

Index

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