Downstream Processing
of Natural Products
A Practical Handbook
edited by Michael Verrall

This highly practical manual guides researchers and industrial workers through the many potential pitfalls involved in the isolation of natural products.

Contributors to this volume, who have wide practical experience of the techniques they describe, present truly state-of-the- art experimental observations and techniques which have not been theoretically rationalized.

Contents

1. Broth Conditioning and Clarification
2. Cell Disruption: A Practical Approach.
3. Solvent Extraction of Fermentation Broth
4. Chemically Assisted Solvent Extraction.
5. Process Integration in Biotechnology
6. Displacement Chromatography
7. Affinity Chromatography
8. High-Performance Liquid Chromatography
9. Lyophilization.
10. Instrumentation and Process Control
11. Scale-Up Considerations
12. GMP and Quality Control

Index

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