Drug-Drug Interactions in Pharmaceutical Development covers the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions.

The book focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market.

Drug-Drug Interactions in Pharmaceutical Development also covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Contents

1. In Vitro evaluation of metabolic drug-drug interactions: concepts and practice
2. In Vitro approaches to anticipating clinical drug interactions
3. Inhibition of drug-metabolizing enzymes and drug-drug interactions in drug discovery and development
4. Mechanism-based CYP inhibition: enzyme kinetics, assays, and prediction of human drug-drug interactions
5. Genomic approaches to drug-drug interactions
6. Transporters and drug interactions
7. Transporter-mediated drug interactions: molecular mechanisms and clinical implications
8. Recent case studies of clinically significant drug-drug interactions and the limits of In Vitro prediction methodology
9. U.S. regulatory perspective: drug-drug interactions
10. Herbal drug interactions—a Canadian perspective

Index

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