Drug Metabolism provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation).

Drug Metabolism is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry.

Contents

1. Drug Metabolism in Context

• Absorption
• Drug Distribution
• Dynamics of Drug Action
• Drug Clearance
• Dynamics of Drug Clearance

2. Pathways of Biotransformation - Phase I Reactions

• Phase I and Phase II Metabolism: General Considerations
• Oxidations Involving the Microsomal Mixed-Function Oxidase System
• Oxidations Involving Other Enzymatic Systems
• Metabolic Reactions Involving Reduction
• Hydrolysis
• Miscellanous Phase I Reactions
• The Fate of Phase I Reaction Products

3. Pathways of Biotransformation - Phase II Reactions

• Glucuronidation
• Acetylation
• Glutathione Conjugation
• Other Conjugative Reactions

4. Enzymatic Systems Involved in Drug Brotransformation

• Interaction Between A Drug Substrate and an Enzyme
• Enzyme Systems with Specific Roles

5. Induction and Inhibition of Drug-Metabolising Enzymes

• Induction
• Inhibition
• Consequences of the Above Phenomena
• Dietary and Non-Dietary Factors in Enzyme Induction and Inhibition

6. Factors that Influence Drug Biotransformation

• Intrinsic Factors
• Environmental Factors

7. Impact of Gene Variability on Drug Metabolism

• Basic Principles of Pharmacogenetics
• Pharmaco-Informatics
• Implications for Third Millennium Medicine

8. Drug Interactions and Adverse Reactions

• Drug-Drug Interactions
• Interactions Between Drugs and Other Entities
• Adverse Reactions

9. Strategies for Drug Design

• Pharmacokinetics and Metabolism in Drug Research
• The Role of Formulation

Index

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