Features:

• Covers the latest developments in all areas of drug delivery systems
• Presents the information in a simple, straightforward, clear, and concise manner
• Provides a global perspective for present and future advances and market opportunities
• Contains input from Wall Street and other global financial institutions
• Includes strategies for dealing effectively with regulatory agencies around the world

Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both industry and academia.

New in this edition:

• Chapter focusing on novel technologies and their global outlook
• Coverage of electronically controlled drug delivery
• Macrocapsules and nanoparticles in drug targeting
• Drug nanocrystals and other new delivery systems
• Updated information on liposomes as carriers

Written in a straightforward, clear, and concise manner, the author provides a global perspective on current and future advances and market opportunities. Drug Delivery Systems, Second Edition answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development.

Contents

SITE-SPECIFIC DRUG DELIVERY

Site-Specific Drug Delivery Using Liposomes as Carriers

• Liposomes in Drug Delivery
• The Liposome-Drug Concept
• Liposomes as Carriers of Therapeutic Agents

Site Specific Drug Delivery Utilizing Monoclonal Antibodies

• Production of Monoclonal Antibodies
• Drug-Monoclonal Antibody Conjugates for Drug Targeting
• Recent Studies with Monoclonal Antibodies

POLYMERS, IMPLANTABLE DRUG DELIVERY

Role of Polymers in Drug Delivery

• Currently Available Polymers
• Soluble Polymers
• Biodegradable or Bioerodible Polymers
• Mucoadhesive Polymers
• Polymers Containing Pendant Substituents
• Matrix Systems
• Heparin Releasing Polymers
• Ionic Polymers
• Oligomers
• Miscellaneous

Implants in Drug Delivery

• Insulin Delivery as a Model Implant Pump System
• Implants for Contraception

ORAL DRUG DELIVERY

Oral Drug Delivery

• Features of the GI Tract
• Targeting of Drugs in the GI Tract
• Design and Fabrication of Oral Delivery systems
• Survey of Oral Controlled Release Products

TRANSDERMANL, INTRANASAL, OCULAR, AND MISCELLANEOUS DRUG DELIVERY

Transdermal Drug Delivery

• Structure of Human Skin
• Theoretical Advantages of the Transdermal Route
• Optimization of Percutaneous Absorption
• Theory for Penetration-Enhancer Activity
• Development of the Transdermal Therapeutic System
• Examples of Transdermal Applications
• Transdermal Controlled-Release Products and Devices

Intranasal and Ocular Drug Delivery

• Intranasal Drug Delivery
• Ocular Drug Delivery

Miscellaneous Forms of Drug Delivery

• Prodrugs
• Infusion Devices
• Insulin Delivery
• Parenteral Prolonged Action Dosage Forms

REGULATORY CONSIDERATIONS AND GLOBAL OUTLOOK

Regulatory Considerations for Drug Delivery Systems

• Current Status of Drug Delivery Technology
• Submission of Documents for Manufacture and Quality

Drug Delivery Industry and the Global Outlook

Index

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