Enhancement in Drug Delivery offers knowledge and elegant tools for the design and development of efficient drug products and new therapies intended for different administration routes.

Features:

• Presents both the basics of administration and methods for enhancement across major routes, including critical information on effectiveness and levels of toxicity
• Offers contributions from worldwide experts in drug delivery and promoted absorption for each route of administration
• Details current strategies to overcome the blood-brain barrier
• Provides consideration of a variety of emerging dermal, nasal, and ocular drug delivery methods
• Considers the complexities involved with peptide delivery
• Discusses the eye, vagina and uterus as drug-absorbing organs

Contents

1. Promoted Gastrointestinal Drug Absorption
2. Gastrointestinal Anatomy, Physiology and Permeation Pathways
3. Enhancers for Enteral Delivery of Macromolecules with Emphasis on Surfactants
4. Improvement of Oral Drug Absorption by Chitosan and its Derivatives
5. Targeted GI Delivery
6. Inhibition of Enzymes and Secretory Transport
7. Enhanced Gastrointestinal Absorption of Lipophilic Drugs
8. Promoted Rectal Absorption
9. Permeation Pathway in Rectal Absorption
10. Cyclodextrins and Other Enhancers in Rectal Delivery
11. Enhancement of Buccal and Sublingual Absorption
12. Basic Biopharmaceutics of Buccal and Sublingual Absorptions
13. Chemical Enhancers in Buccal and Sublingual Absorptions
14. Transdermal Enhanced Delivery
15. The Lipid Organization in Stratum Corneum and Model Systems Based on Ceramides
16. Chemical Permeation Enhancement
17. Vesicular Carriers for Enhanced Delivery through the Skin
18. Iontophoresis in Transdermal Delivery
19. Electroporation as a Mode of Skin Penetration Enhancement
20. Ultrasound in Percutaneous Absorption
21. Combined Chemical and Electroporation Methods of Skin Penetration Enhancement
22. Stratum Corneum Bypassed or Removed
23. Nasal Absorption Optimization
24. Physiological Factors Affecting Nasal Drug Delivery
25. Nasal Delivery of Peptide Drugs
26. Drug Absorption from Vagina and Uterus
27. Vagina and Uterus as Drug-Absorbing Organs
28. Strategies to Improve Systemic and Local Availability of Drugs Administered via Vaginal Route
29. Systemic Absorption through the Ocular Route
30. Eye Structure and Physiological Functions
31. Drug Delivery Systems for Enhanced Ocular Absorption
32. Ocular Penetration Enhancers
33. Iontophoresis for Ocular Drug Delivery
34. Drug Delivery to the Central Nervous System
35. Structure and Function of the Blood-Brain Barrier
36. Strategies to Overcome the Blood-Brain Barrier

Index

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