The 6th edition of the Handbook of Basic Pharmacokinetics… including Clinical Applications is designed as a user-friendly consolidation of the principles and techniques of pharmacokinetics.

Thirteen of the previous edition’s 38 chapters are updated to include advances in the field. Pharmacokinetic data profiles on an additional 220 drugs have been added to the Appendix, which now provides accessible information on more than 640 drugs.

Key Features:

• Thirteen of the previous edition’s 38 chapters are updated to capture the most relevant new scientific information
• New chapter entitled “Pharmacogenetics and Pharmacogenomics” was created in recognition of the influence of genetic constitution on the enzymes and transporters that affect drug disposition and action
• Appendix presents pharmacokinetic data on more than 640 important drugs—more than 220 new to this edition—in an accessible tabular format
• A wealth of useful figures (numbering 130) and tables (90)
• Glossary and Index

Contents

1. Definitions and Glossary updated
2. The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response
3. Organs, Tissues, Cells, and Organelles
4. Cell Membranes—Structure, Functions, and Properties updated
5. Drug Receptor Interactions. Absorption/Transport Mechanisms updated
6. PKa and Degree of Ionization
7. Lipid/Water Partition Coefficient
8. Physico-Chemical Factors Altering Biological Performance of Drugs
9. Biopharmaceutical Data of the Gastrointestinal Tract updated
10. Fluid Compartments and Circulatory System (Blood and Lymph)
11. Drug Biotransformation updated
12. Compartment Models
13. Determination of Rate Constants
14. Volume of Distribution and Distribution Coefficient
15. Excretion and Clearance of Drugs updated
16. Urinary and Biliary Recycling updated
17. Cumulative Urinary Excretion
18. Area Under the Blood Level-Time Curve
19. Pharmacokinetics of Single Dose Administration
20. Pharmacokinetics of Multiple Dosing
21. Compartment Model Independent Analysis
22. Pediatric Pharmacokinetics updated
23. Drug Dosage in Elderly Patients
24. Drug Dosage in Obese Patients
25. Drug Disposition in Pregnancy updated
26. Dosage Regimen Design updated
27. Drug Monitoring and Dose Adjustment
28. Physiological and Pathological Factors Influencing Drug Response updated
29. First Dose Size in Man
30. Forensic Pharmacokinetics
31. Nonlinear Pharmacokinetics
32. Curve Fitting
33. Correlation of Clinical Response with Drug Disposition
34. Bioavailability and Bioequivalence updated
35. Body Surface Area. Extracorporeal Methods of Drug Removal updated
36. Pharmacogenetics and Pharmacogenomics

Appendix
Index

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