Handbook of Pharmaceutical Granulation Technology explains how new and emerging technologies are utilized in the production of pharmaceutical granulation-demonstrating cost-effective strategies to manufacture solid-dosage forms with consistent physical properties while complying with current regulatory requirements.

Features:

• New chapters on granulation process modeling, scale-up considerations in granulation, rapid release granulation techniques, melt granulation and pelletization, effervescent granulation, rapid release granulation, and process analytical technology (PAT)
• Updated sections on the theory of granulation from an engineering perspective, as well as the most recent regulatory standards and technologies employed in industry, methods to produce pharmaceutical granulation, and the spray drying techniques
• In-depth analyses of a number of different dosage forms utilizing varying granulation technologies to keep readers at the forefront of technological advancement
• A wide spectrum of granulation methods

Contents

• Theory of Granulation
• Drug Substance and Excipient Characterization
• Binders and Solvents
• Spray Drying
• Roller Compaction
• High Shear Granulation
• Low Shear Granulation
• Batch Fluid Bed Processing
• Single Pot Processing
• Extrusion/ Spheronization
• Effervescent Granulation
• Melt Granulation and pelletization
• Rapid Release Granulation
• Continuous Granulation
• Scale up considerations in Granulation
• Sizing of the Granulations
• Granulation Characterization
• Bioavailibility and Granule Properties
• Process Analytical Technology (PAT)
• Granulation Process Modeling
• Regulatory Issues in Granulation

Index

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