Second Edition
edited by Andreas von Recum

Handbook of Biomaterials Evaluation addresses the needs of those who are involved in inventing, developing, and testing implants and are concerned about the interactions between biomaterial and body tissue. The authors explore the physical, chemical, mechanical and regulatory considerations of synthetic materials used in surgical and implant procedures, and how these factors impact the latest developments and new approaches.

This updated edition provides the biomaterials professional with necessary information on a range of issues, including bulk characterization, surface evaluations, toxicological evaluations, in vitro methods for safety evaluation, methods for evaluating materials in special applications, surgical considerations, systems implantology, soft and hard tissue history, regulatory aspects, and clinical trials.

Contents

1. Metals Alloys and Ceramics
2. Polymers
3. Composites
4. Dental Materials
5. Textiles
6. Absorbable Materials and Pertinent Devices
7. Biomaterial Surface Analysis
8. Ceramics and Glasses
9. Corrosion and Biodegradation
10. Friction and Wear
11. Reference Materials
12. Property Modification
13. Surface Topography
14. Particulate Material
15. Sterilization Effects
16. Perspectives
17. Testing
18. Hypersensitivity Induction
19. Tumor Induction
20. In-Use Testing of Biomaterials in Biomedical Devices
21. Mammalian Cell Culture Models
22. Hemocompatability: Effects on Cellular Elements
23. Hemocompatability: Effects on Humoral Elements
24. Genotoxicity
25. Tissue Engineering Concepts
26. Immunoisolation Devices
27. Drug Delivery Systems
28. Biosensors
29. Protection Of Research Animals
30. Animal Selection
31. Surgical Procedure
32. Implant Infections
33. General Compatibility
34. Hemocompatability
35. Osteocompatability
36. Odontocompatability
37. Tissue Preparation
38. Evaluation By Light Microscopy
39. Evaluation by Scanning Electron Microscopy
40. Evaluation by Histiochemical and Quantitative Microscopy
41. Evaluation Through Molecular and Cellular Biology Approaches
42. The Cage Implant Testing System
43. Evaluation of Explanted Cardiovascular Prostheses
44. Processing
45. Special Aspects of the Permucosal Interface
46. Intra Vitam Staining Techniques
47. Quantitative Morphology of the Implant-Bone Interface
48. Microradiography
49. Legal Aspects
50. Pre-clinical Testing Guidelines
51. Clinical Trial Guidelines
52. Protection of Human Subjects
53. Patient Selection
54. Multiphasic Device Testing
55. Design of Clinical Trials
56. Malpractice Risk in Clinical Trials
57. Information for the Public
58. Toxicological Evaluations
59. In Vitro Assessment of Safety
60. Active Implants
61. Implantology
62. Soft Tissue Histology
63. Hard Tissue Histology
64. Regulations
65. Clinical trials

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