The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study.

Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health.

Contents

Volume I: Molecular Biology and Biochemistry

1. Tuberculosis
2. Molecular Genetics and Biochemistry: Introduction
3. Biochemistry of the Cell Wall
4. Glycolipids and Polyketides of M. tuberculosis
5. Physiology of M. tuberculosis
6. Nutrient Transport
7. Iron Uptake by M. tuberculosis
8. Protein Transport
9. PE and PPE Gene Family Members in M. tuberculosis
10. Virulence/Persistence Mechanisms of M. tuberculosis
11. Genomics
12. Transcriptomics and Transcriptional Regulation
13. Proteomics of M. tuberculosis
14. Structure
15. Molecular Mechanisms of Dormancy and Resuscitation
16. M. tuberculosis in the Phagosome
17. Molecular Mechanisms of Drug Resistance of M. tuberculosis
18. Experimental Genetics of M. tuberculosis
19. Molecular Evolution of Mycobacteria

Volume II: Immunology and Cell Biology

1. Introduction: Immunity to M. tuberculosis and BCG
2. Recognition Receptors and Phagocytosis for M. tuberculosis
3. Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis
4. Dendritic Cells and Antigen Presentation
5. Killing Mechanisms of the Host Against M. tuberculosis
6. Manipulation of the Macrophage Response
7. Conventional T Cells and their Antigenic Repertoire
8. Unconventional T Cells
9. Cytokines in Tuberculosis
10. Antibodies in Tuberculosis
11. Pathology
12. Maintenance of Latent Infection with Correlates of Protective Immunity
13. Genetics of Resistance (mouse and man)
14. HIV/TB Interactions
15. Novel Vaccination Strategies Against Tuberculosis
16. Experimental Animal Models of Tuberculosis

Volume III: Clinics, Diagnostics, Therapy and Epidemiology

1. Clinics Diagnostics Therapy Epidemiology: Introduction
2. Global Epidemiology of Tuberculosis
3. Surveillance Studies and Interpretation
4. Molecular Epidemiology of M. tuberculosis
5. Diagnosis of M. tuberculosis: Clinical
6. Clinical Disease (with and without HIV)
7. Management of Tuberculosis Patients
8. Chemotherapy
9. New Drugs and Clinical Drug Trials
10. Latency
11. Drug Resistance in Clinical Context
12. Novel Drug Treatment Strategies -
13. Co-infections
14. Modeling
15. BCG Vaccination

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