Features:

• Detailed descriptions of laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments

• Discussion of general methods including experimental design and statistical evaluations, non-surgical and surgical techniques, anesthesia, and post-mortem examinations

• Thoroughly revised chapters on occupational health, techniques and procedures in genetic engineering, and experimental design and statistics

• Expanded coverage of safety and security in laboratory animal facilities, humane endpoints and the treatment of pain in lab animals, surgical techniques, minimal access techniques, Australasian legislation and regulation of the use of lab animals, and the use of the Web as a resource

• New, streamlined chapter combines the review of alternative techniques to animal experimentation with the use of isolated organs, cell cultures, and computer simulations

The Second Edition of an international bestseller, Handbook of Laboratory Animal Science Volume 1 provides veterinary specialists as well as veterinary and biomedical researchers with detailed information about laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments.

Completely revised and updated, Volume I now contains expanded coverage of topics such as procedures in genetic engineering, surgical techniques, and humane endpoints and the treatment of pain and suffering in laboratory animals. It also includes a new, streamlined chapter that combines the review of alternative techniques to animal experimentation such as the use of isolated organs, cell cultures, and computer simulations.

Contents

1. The Contribution of Laboratory Animals to Medical Process
2. Animal Research Ethics
3. An Overview of Global Legislation, Regulation and Policies on the Use of Animals for Scientific Research, Testing or Education
4. Assessment of Animal Care and Use Programs and Facilities
5. Education and Training
6. Laboratory Animal Science and Service Organizations
7. Laboratory Animal Allergy
8. Equipment for Conventional, Barrier, and Containment Housing Systems
9. Laboratory Animal Genetics and Genetic Quality Control
10. Phenotypic Characterization of Genetically Engineered Mice
11. Health Status and Health Monitoring
12. Nutrient Requirements, Experimental Design and Feeding Schedules in Animal Experimentation
13. Impact of the Biotic and Abiotic Environment on Animal Experiments
14. Experimental Design and Statistical Analysis
15. Common Nonsurgical Techniques and Procedures
16. Production of Polyclonal and Monoclonal Antibodies
17. Laboratory Animal Analgesia, Anesthesia and Euthanasia
18. Welfare Assessment and Humane Endpoints
19. Surgery: Basic Principles and Procedures
20. Microsurgical Procedures in Experimental Research
21. Postmortem Procedures
22. Alternatives: Refinement, Reduction and Replacement of Animal Use in the Life Sciences

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