Handbook of Meningococcal Disease is a comprehensive overview of recent advances, from current basic research and epidemiology, to novel therapeutic strategies and clinical management.

Features:

• Provides up-to-date reviews and describe their current knowledge and concepts
• Summarizes the implications of the meningococcus genome-sequencing project, emphasizing the novel strategies in vaccine development
• Covers cross-talk between meningococci and host cells, genomics and immunobiology

Contents

1. Historical Aspects
2. The Population Biology of Neisseria meningitidis: Implications for Meningococcal Disease, Epidemiology and Control
3. Methods for Typing of Meningococci
4. Antibiotic Resistance
5. Neisseria meningitidis Genome Sequencing Projects
6. Phase Variation and Adaptive Strategies of N. meningitidis: Insights into the Biology of a Commensal and Pathogen
7. Meningococcal Transformation and DNA Repair
8. Structure and Genetics of the Meningococcal Capsule
9. Genetics, Structure and Function of Lipopolysaccharide
10. Major Outer Membrane Proteins of Meningococci
11. Iron Metabolism in Neisseria meningitidis
12. Genetics, Structure and Function of Pili
13. Mechanisms of Attachment and Invasion
14. Role of Complement in Defense Against Meningococcal Infection
15. Cellular Immune Responses in Meningococcal Disease
16. Surrogates of Protection
17. Conjugate Vaccines
18. Outer Membrane Vesicle-based Meningococcal Vaccines
19. Genome Mining and Reverse Vaccinology
20. Vaccination for the Control of Meningococcal Disease: the Use of Meningococcal Vaccines from the Public Health Perspective
21. Pathogenesis and Pathophysiology of Invasive Meningococcal Disease
22. Course of Disease and Clinical Management
23. Public Health Manage

Index

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