Handbook of Mouse Models of Cardiovascular Disease includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the mode.

Features:

• Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis
• Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure
• Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems
• Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology

Contents

1. General information
2. Naturally occurring variation among mouse strains
3. Transgenic and Gene-targeted Mice of Hyperlipidemia
4. Bone Marrow Transplantation: the methodology and its application in atherosclerosis research
5. Hyperlipidemia-induced Atherosclerosis
6. Magnetic Resonance Imaging Evaluation of Atherosclerotic Plaque
7. Plaque Rupture
8. Perivascular Cuff-, Electronic- and Chemical Injury-induced Stenosis
9. Flow-induced Vascular Remodeling Vycheslav
10. Vein Graft Atherosclerosis
11. Angiotensin II-induced aortic aneurysms
12. Carotidojugular Fistula
13. Applications to the Study of Stroke
14. Identifying Congenital Heart Defects in Embryos Using High-resolution Magnetic Resonance Imaging
15. Allograft Arteriopathy: Heterotopic Heart Transplantation and Aortic Interposition Grafts
16. Heart Preconditioning Analysis
17. Myocardial Ischemia–Reperfusion
18. Cardiac Hypertrophy
19. The Retrogradely Perfused Isolated Heart Model
20. Measurement of Pulse Wave Velocity
21. Gene Transfer to Dyslipidemic Mice
22. Hypertension
23. Ischemia-induced Neovascularisation
24. Angiogenesis in Biomatrices and Artificial Materials
25. Venous Thrombosis
26. Virus-induced Vasculitis
27. Surgically induced Chronic Heart Failure
28. Atrial Fibrillation

Index

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