edited by David Kozma

• All of the information needed to perform, develop, and optimize optical resolutions through diastereomeric salt formation

• A database of resolving agents, resolved compounds sorted according to the resolving agent, and suppliers of commercially available resolving agents

• Descriptions of several resolution processes

• A practical guide for determining enantiomeric purity

• More than 100 tables, 4,200 citations, and data on 3,500 resolutions

Handbook of Optical Resolutions Via Diastereomeric Salt Formation is the first book to exclusively address this important organic chemical process. It provides fast, one-stop access to a wealth of information, including all of the available data on 100 resolving agents, a list of 500 optically active compounds available in bulk along with their suppliers, data on more than 3,500 resolutions, and 4,200 citations.

This handbook helps answer virtually any question that may arise during the development of a new resolution process.

• Which resolving agent and solvent should I use under these conditions?

• How can I separate the diastereoisomers?

• How can I optimize a resolution process?

• How do I determine enantiomeric purity?

• Which supplier has the resolving agent I need?

• For a racemate already resolved, what were the resolving agent, solvent, and relevant citation?

This is the first book to deal exclusively with all aspects of this important organic chemical process, both theoretical and practical. With an abundance of analyzed examples, this single, authoritative reference provides all of the information you need to perform, develop, and optimize optical resolutions via Diastereomeric salt formation.

Contents

1. Introduction
2. Basic Concepts and Nomenclature of Stereochemistry
3. Resolution by Formation and Fractional Crystallisation of Diastereometric Salts
4. Resolving Agents
5. Research on Resolving Agents
6. Selection of the Resolving Agent
7. Selection of the Resolving Agent by Experimentation
8. Selection of a Resolving Agent Based on the Determination of Physico-Chemical Parameters
9. Selection of the Resolving Agent Based on Theoretical Considerations
10. Resolution in Practice, Selection of the Optimal Parameters
11. Alternative Methods of Resolution by Diastereometric Salt Formation
12. Detailed Descriptions of Selected Resolutions

Appendix 1: Resolutions Ordered According to the Resolving Agent
Appendix 2: Commercially Produced Resolving Agents and Optically Active Industrial Products which may be Eligible as Resolving Agents
Appendix 3: Chiral Selective Chromatographic Analysis

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