by Sue Campbell
Williams Hematology covers the newest developments in genetics and molecular biology, sickle cell diseases, gene rearrangements, platelet morphology, biochemistry, function, and so much more.
Features:
- New developments in the genetics and the molecular pathogenesis of blood cell disorders
- Extensive treatment of cytokine and chemokine networks in blood cell regulation
- The most recent diagnostic and treatment approaches to blood and lymphomic disorders
- Advances in the management of the lymphomas and lymphocytic leukemias
- Comprehensive descriptions of the diagnosis and management of the cloncal myeloid diseases
- The most recent concepts of diseases of platelets and the management of hemostatic and thrombotic diseases
- Thoroughly updated classic treatments of a variety of patient populations, from infants to the elderly
Contents
Clinical Evaluation of the Patient
- Initial Approach to the Patient: History and Physical Examination
- Examination of the Blood
- Examination of the Marrow
General Hematology
- Structure of the Marrow and the Hematopoietic Microenvironment
- The Lymphoid Tissues
- Hematology of the Newborn
- Hematology During Pregnancy
- Hematology in Older Persons
Molecular and Cellular Hematology
- Genetic Principles and Molecular Biology
- Cytogenetics and Gene Rearrangement
- Apoptosis
- Cell Cycle Regulation and Hematological Disorders
- Signal Transduction Pathways
- The Cluster of Differentiation(CD) Antigens
- Hematopoietic Stem Cells, Progenitors, and Cytokines
- The Inflammatory Response
- Innate Immunity
- Dendritic Cells and the Control of Innate and Adaptive Immunity
Therapeutic Principles
- Pharmacology and Toxicity of Antineoplastic Drugs
- Treatment of Infections in the Immunocompromised Host
- Principles of Antithrombotic Therapy
- Principles of Hematopoietic Cell Transplantation
- Principles of Immune Cell Therapy
- Principles of Vaccine Therapy
- Principles of Therapeutic Apheresis: Indications, Efficacy, Complications
- Principles of Gene Transfer fot Therapy
- Pain Management
The Erythrocyte
- Morphology of the Erythron
- Composition of the Erythrocyte
- Production of Erythrocytes
- Destruction of Erythrocytes
- Clinical Manifestations and Classification of Erythrocyte Disorders
- Aplastic Anemia
- Pure Red Cell Aplasia
- Anemia of Chronic Renal Failure
- Anemia of Endocrine Disorders
- The Congenital Dyserythropoietic Anemias
- Paroxysmal Nocturnal Hemoglobinuria
- Folate, Cobalamin, and Megaloblastic Anemias
- Disorders of Iron Metabolism
- Anemia Resulting from Other Nutritional Deficiencies
- Anemia Associated with Marrow Infiltration
- Anemia of Chronic Disease
- Disorders of the Red Blood Cell Membrane: Hereditary Spherocytosis, Elliptocytosis, and Related Disorders
- Disorders of Red Cells Resulting from Enzyme Abnormalities
- Disorders of Globin Synthesis: The Thalassemias
- Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities
- Methemoglobinemia and Other Causes of Cyanosis
- Hemolytic Anemia Resulting from Physical Injury to Red Cells
- Hemolytic Anemia Resulting from Chemical and Physical Agents
- Hemolytic Anemia Resulting from Infections with Microorganisms
- Hemolytic Anemia Resulting from Immune Injury
- Alloimmune Hemolytic Disease of the Newborn
- Acute Blood Loss Anemia
- Hypersplenism and Hyposplenism
- Primary and Secondary Polycythemias (Erythrocytosis)
- The Hematologic Aspects of Porphyria
- Hereditary and Acquired Sideroblastic Anemias
Neutrophils, Eosinophils, Basophils, and Mast Cells
- Morphology of Neutrophils, Eosinophils, and Basophils
- Composition of Neutrophils
- Production, Distribution, and Fate of Neutrophils
- Eosinophils and Their Disorders
- Basophils and Mast Cells and Their Disorders
- Classification and Clinical Manifestations of Neutrophil Disorders
- Neutropenia and Neutrophilia
- Disorders of Neutrophil Function
Monocytes and Macrophages
- Morphology of Monocytes and Macrophages
- Biochemistry and Function of Monocytes and Macrophages
- Production, Distribution, and Fate of Monocytes and Macrophages
- Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages
- Monocytosis and Monocytopenia
- Inflammatory and Malignant Histiocytosis
- Lipid Storage Diseases
Lymphocytes and Plasma Cells
- Morphology of Lymphocytes and Plasma Cells
- Composition and Biochemistry of Lymphocytes and Plasma Cells
- Lymphopoieses
- Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production
- Functions of T Lymphocytes: T Cell Receptors for Antigen
- Functions of Natural Killer Cells
- Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders
- Lymphocytosis and Lymphocytopenia
- Immunodeficiency Diseases
- Hematological Aspects of Human Immunodeficiency Syndrome
- Mononucleosis Syndromes
Malignant Diseases
- Classification and Clinical Manifestations of the Clonal Myeloid Disorders
- Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Leukemia)
- Acute Myelogenous Leukemia
- Chronic Myelogenous Leukemia and Related Disorders
- Idiopathic Myelofibrosis (Myelofibrosis with Myeloid Metaplasia)
- Classification of Malignant Lymphoid Disorders
- Acute Lymphoblastic Leukemia
- Chronic Lymphocytic Leukemia and Related Disorders
- Hairy Cell Leukemia
- Large Granular Lymphocytic Leukemia
- Pathology of Lymphomas
- The Non-Hodgkin Lymphomas
- Hodgkin Lymphoma
- Plasma Cell Neoplasms: General Considerations
- Essential Monoclonal Gammopathies
- Plasma Cell Myeloma
- The Amyloidoses
- Macroglobulinemia
- Heavy Chain Diseases
Hemostasis and Thrombosis
- Megakaryopoiesis and Thrombopoiesis
- Platelet Morphology, Biochemistry, and Function
- Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
- Control of Coagulation Reactions
- Vascular Function in Hemostasis
- Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
- Thrombocytopenia
- Essential Thrombocythemia and Thrombocytosis
- Hereditary Qualitative Platelet Disorders
- Acquired Qualitative Platelet Disorders
- The Vascular Purpuras
- Hemophilia A and Hemophilia B
- Inherited Deficiencies of Coagulation Factors II, V, VII, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors
- Hereditary Fibrinogen Abnormalities
- Von Willebrand Disease
- Antibody-Mediated Coagulation Factor Deficiencies
- Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation
- Disseminated Intravascular Coagulation
- Hereditary Thrombophilia
- The Antiphospholipid Syndrome
- Anti-body Mediated Thrombotic Disorders: Idiopathic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia
- Venous Thrombosis
- Atherothrombosis: Disease Initiation, Progression, and Treatment
- Fibrinolysis and Thrombolysis
Transfusion Medicine
- Erythrocyte Antigens and Antibodies
- Human Leukocyte and Platelet Antigens
- Blood Procurement and Screening
- Preservation and Clinical Use of Erythrocytes and Whole Blood
- Preservation and Clinical Use of Platelets
Index
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