Hemostasis and Thrombosis integrates basic science and clinical practice and details all that is currently known about blood clotting disorders and how to manage patients with these and related problems.
Contents
Part I: Basic Principles of Hemostasis and Thrombosis
Coagulation and its Regulation
- Overview of Coagulation, Fibrinolysis, and Their Regulation
- The Blood Coagulation Factors: Their Complementary DNAs, Genes, and Expression
- Genetics of Coagulation
- Tissue Factor Structure and Function
- Contact Activation (Kallikrein-Kinin) Pathway: Multiple Physiologic and Pathophysiologic Activities
- Molecular and Structural Biology of Factor IX
- Factor VIII and Hemophilia A
- Factor V
- Thrombin
- Protein Z and Protein Z-Dependent Protease Inhibitor
- Factor XI
- Antithrombin III and Heparin Cofactor II
- Protein C, Protein S, and Thrombomodulin
- Heparin and Vascular Proteoglycans
Fibrinolysis and its Regulation
- Fibrinogen Structure and Physiology
- Factor XIII And Fibrin Stabilization
- Plasminogen-Plasmin System
- Plasminogen Activator Inhibitor-1
- Thrombonin-Activatable Fibrinolysis Inhibitor aka Procarboxypeptidase U
- x-Macroglobulins and Kunins
- Human Endothelial Cell Plasmin-Generating System
- Physiologic Regulation of Fabrinolysis
Platelet Structure and Function
- Overview of Platelet Structure and Function
- Platelet Production: Cellular and Molecular Regulation
- Platelets: Structure Related to Function
- Thrombopoietin
- Platelet Glycoprotein Polymorphisms and Relationship to Function, Immunogenicity, and Disease
- Molecular Mechanisms of Drug-Induced Thrombocytopenia
- Integrin xIIbß3 and Platelet Aggregation
- The Platelet Glycoprotein Ib/IX/V Complex and Platelet Adhesion
- Platelet Adenosine 5'-Diphosphate Receptors
- Protease-Activated Receptors in Hemostasis, Thrombosis, and Vascular Biology
- Platelet-Collagen Receptors
- Platelet Prostanoid Receptors
- Platelet Eicosanoids
- Platelet and Megakaryocyte Lipids
- Role of Platelets in Blood Coagulation
- Platelet Signal Transduction
Vascular Biology, Embryogenesis, Development, and Disorders
- Overview of Vascular Biology, Embryogenesis, Development, and Disorders
- Development of the Vascular System
- The Vascular Biology of Nitric Oxide and Nitric Oxide Synthases
- Vascular Adaptations to Altered Blood Flow
- Angiogenesis, Lymphangiogenesis, and Vascular Morphogenesis
- Monocyte-Platelet-Endothelial Interactions
- Structure and Function of von Willebrand Factor
- Platelet-Vessel Wall Interactions in Flowing Blood
- Rheology of Thrombosis
- Biomaterial-Associated Thrombosis
- The Vascular Response to Injury
- Vessel Wall Lipids
- Thrombophilia Genetics
- Inflammation and Atherothrombosis
- Histopathology of Atherosclerosis
- Laboratory Markers of Platelet Activation
- Laboratory Markers of Coagulation and Fibrinolysis
- Malignancy and Hemostasis
Part II: Clinical Applications
Inherited Hemorrhagic Disorders
- Overview of Inherited Hemorrhagic Disorders
- Clinical Manifestations and Therapy of the Hemophilias
- von Willebrand Disease: Diagnosis, Classification, and Treatment
- Inherited Disorders of Prothrombin Conversion
- Afibrinogenemias and Dysfibrinogenemias
- Familial Multiple Coagulation Factor Deficiencies
- Hereditary Disorders of Platelet Secretion and Signal Transduction
- Inherited Thrombocytopenias
- Inherited Abnormalities of the Platelet Membrane: Glanzmann Thrombasthenia, Bernard-Soulier Syndrome, and Other Disorders
- Primary Vascular Disorders
Acquired Hemorrhagic Disorders
- Hemostatic Abnormalities in Liver Disease
- Clinical Disorders of Fibrinolysis
- Acquired Qualitative Platelet Defects
- Acquired Disorders of Coagulation: The Immune Coagulopathies
- Immune Thrombocytopenic Purpura
- Drug-Induced Thrombocytopenia
- Hemostatic Problems in Surgical Patients
- Obstetric Hemorrhage
Therapy of Bleeding Disorders
- Clinical Approach to the Bleeding Patient
- Management of Acute Hemorrhage
- Therapy with Antifibrinolytic Agents
- Transfusion Medicine Platelet Transfusion Therapy, Plasma, and Plasma Concentrates
- New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy
Venous Thromboembolic Disorders
- Overview of Venous Thromboembolism
- Epidemiology of Venous Thromboembolism
- Women's Health and Venous Thromboembolism
- Cancer and Thrombosis
- Venous Thrombosis in Unusual Sites
- Diagnosis of Venous Thromboembolism
- Risk Stratification in Patients with Pulmonary Embolism
- Treatment of Venous Thromboembolism
- Thrombolysis in Venous Thromboembolic Disease
- Mechanical Devices and Embolectomy
- Chronic Thromboembolic Pulmonary Hypertension
- Paradoxical Embolism
- Prevention of Venous Thromboembolism in General Surgery
- Prevention of Venous Thromboembolism in Orthopedic Surgery
- Venous Thromboprophylaxis in Medical Patients
Cardiovascularthrombotic Diseases
- Acute Coronary Syndromes
- Antithrombotic Therapy for Percutaneous Coronary Intervention
- Coronary Bypass Grafting and Cardiac Surgery
- Medical Therapy for Peripheral Arterial Disease
- Surgery for Peripheral Arterial Disease
- Prevention and Treatment of Acute Stroke
- Interdisciplinary Management of Acute Stroke
- Antithrombotic Therapy for Patients with Atrial Fibrillation
- Advanced Cardiomyopathy and Surgery
- Valvular Heart Disease
- Overview of Complex Thrombohemorrhagic Disorders
Complex Thrombohemorrhagic Disorders
- Myeloproliferative Disorders and Thrombohemorrhagic Complications
- Consumptive Thrombohemorrhagic Disorders
- Coagulation Abnormalities in Sepsis
- Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome
- Antiphospholipid Antibodies and the Anitphospholipid Syndrome
- Thrombosis in Infancy and Childhood
- Heparin-Induced Thrombocytopenia
- Coumarin-Induced Skin Necrosis and Venous Limb Gangrene
Therapy, New Directions, and Complications in Thrombotic Disorders
- Anticoagulant Therapy for Major Arterial and Venous Thromboembolism
- Anticoagulation Clinics
- Drug Interactions with Oral Anticoagulants
- Hemorrhagic Complications of Anticoagulation
- Antiplatelet Therapy
- Foundations of Thrombolytic Therapy
- New Thrombolytic Agents
- New Antithrombotic Drugs
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