Iminosugars: From Synthesis to Therapeutic Applications provides an up-to-date account of many contemporary aspects of iminosugars from organic synthesis to clinical studies.

Features:

• An up-to-date account of many contemporary aspects of iminosugars from organic synthesis to clinical studies
• Iminosugars are lead compounds for drug development in a variety of therapeutic areas
• Contributions by the major world experts in the field
• A table correlating the structures of all reported iminosugars with their biological activities, whenever such data are available

Contents

1. Iminosugars: past, present and future
2. Naturally occurring iminosugars and related alkaloids: structure, activity and applications
3. General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries
4. Iminosugar C-glycosides: synthesis and biological activity
5. Imino-C-disaccharides and analogues: synthesis and biological activity
6. Isofagomine, noeuromycin and other 1-azasugars, iminosugar related glycosidase inhibitors
7. Iminosugar-based glycosyltransferase inhibitors
8. Transition state analogue inhibitors of N-Ribosyltransferases
9. Iminosugars as antiviral agents
10. Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders
11. Iminosugar inhibitors for substrate reduction therapy for the lysosomal glycosphingolipidoses
12. Iminosugar-based antitumoural agents
13. Medicinal use of iminosugars
14. Tables of iminosugars, their biological activities and their potential as therapeutic agents

Index

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