Immunodominance summarizes the current concepts and brings together in one volume the critical arguments concerning the mechanisms relevant to immunodominance.

Features:

• Mechanics of antigen processing
• Proteosome specificity and immuno-proteosomes
• Effect of the T cell repertoire on dominance
• Effects of pathogens on the immune response

Contents

Class I MHC Antigen Processing

• Properties of MHC
• Properties of Peptides
• Cytosolic Processing
• Peptide Transport
• Class I MHC Maturation and Peptide Loading
• Immunodominance and Class I MHC Peptide Processing

The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy

• Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments
• Phase II: Antigen Internalization and Processing
• Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules

The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance

• MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance
• Previous Systematic Analysis of Immunodominance by Our Group
• Cellular and Molecular Events in Immunodomination
• Speculations on the Mechanism of Immunodomination
• Significance of Studying Immunodominance for Vaccine Development

Endogenous Antigen Processing

• Unbottling the Genie
• DRiPs to the Rescue
• The Ubiquitin–Proteasome Pathway
• Pressing TDH Questions
• What Does This Have to Do With Immunodominance

Regulation of EarlyT-C ell Development in the Thymus

• T-Cell Development in the Thymus
• In Vitro T-cell Development

CD8 T-cell Immunodominance, Repertoire, and Memory

• CD8 T-Cell Responses and Memory
• Analyzing the Memory Repertoire
• Immunodominance
• Epitope-dependent Skewing of the Repertoire During Primary, Memory, and Recall Responses
• Heterologous Infections and Immunodominance
• Chronic Infections and T-cell Heterogeneity
• Repertoire Limitation and Immunodominance
• Impact of Epitope Variation

Listeria monocytogenes Infection and the CD8+ T-Cell Hierarchy

• Innate Immune Response to LM
• Adaptive Immune Response to LM and Ag Presentation
• Secreted Versus Non-secreted Ag
• The Hierarchy of the CD8+ T-cell Responses to LM Epitopes
• IFN-c and the CD8+ T-cell Hierarchy
• Timing of Ag Presentation and the CD8+ T-cell response

Immunodominance in Tuberculosis

• Immune Responses to Mycobacterium tuberculosis
• BC ells
• CD4 T Cells
• CD8 T Cells
• Antigen Processing and Presentation of Mtb Antigens
• How Does Infection with Mtb Differ from Other Acute or Chronic Infections
• Immunodominance in the CD4 T-cell Response
• Immunodominance in the CD8 T-cell Response
• Non-classically Restricted T Cells in TB

T-Cell Specificity and Respiratory Virus Infections

• Primary Immune Responses to Respiratory Virus Infections
• Specificity of the Primary Immune Response
• T-Cell Memory to Respiratory Virus Infections
• The Specificity of Memory T Cells
• Recall Responses to Secondary Infections
• Immunodominance Patterns in Recall Responses
• Modification of Immunodominance Hierarchies by Vaccination

Effects of Pathogens on the Immune Response: HIV

• Identification of HIV-1 CTL Epitopes
• Immunodominant HIV-1 Epitopes Presented by HLA Alleles Associated With Slow Progression to AIDS and Their Escape Mutants
• Immunodominant HIV-1 Epitopes Presented by HLA Alleles Associated With Rapid Progression to AIDS
• Immunodominant HIV-1 Epitopes Presented by Other HLA Alleles
• Escape Mutations and Viral Fitness
• Effect of Nef-mediated HLA Class I Downregulation on Recognition of HIV-1-infected CD4+ T Cells by HIV-1-specific CD8+ T Cells
• Skewed Maturation of HIV-1-specific CD8+ T Cells

The Effects of Pathogens on the Immune System: Viral Hepatitis

• The Viruses and the Disease
• Importance of CD4 and CD8 T Cells in HBV and HCV Control
• Limitations of Existing Data
• Hierarchy of T-cell Responses During HBV Infection: Helper CD4 T-cell Response
• Hierarchy of T-cell Responses During HBV Infection: Cytotoxic T-cell Response
• Hierarchy of HCV Proteins
• Hierarchy of HCV Epitopes
• Immunodominance and Liver Pathology

Immunodominance in the T-Cell Response to Herpesviruses

• Immunodominance in the CD8 T-Cell Response to the Three Classes of Herpesvirus

Index

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