Immunogenomics and Human Disease provides an overview of key conceptual and molecular technologies being deployed in immunogenomics.

Features:

• Includes detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection

Contents

1. Genotyping methods and disease gene identification
2. Glycomics and the Sugar Code: Primer to their Structural Basis and Functionality
3. Proteomics in Clinical Research: Perspectives and Expectations
4. Chemical genomics: bridging the gap between novel targets and small molecule drug candidates. Contribution to immunology
5. Genomic and proteomic analysis of activated human monocytes
6. Bioinformatics as a problem of knowlege representation: applications to some aspects of immunoregulation
7. Chemokines regulate leukocyte trafficking and organ-specific metastasis
8. Towards a unified approach to new target discovery in breast cancer: combining the power of genomics, proteomics and immunology
9. Genomics and Functional Differences of Dendritic Cell Subsets
10. Systemic lupus erythematosus: new ideas for diagnosis and treatment
11. Immunogenetics of experimentally induced arthritis
12. Synovial activation in rheumatoid arthiritis
13. T cell epitope hierarchy in experimental autoimmune models
14. Gene–gene interactions in immunology as exemplified by studies on autoantibodies against 60 kDa heat-shock protein
15. Histamine genomics and metabolomics
16. The histamine H4 receptor: drug discovery in the post-genomic era
17. Application of microarray technology to bronchial asthma
18. Genomic investigation of asthma in human and animal models
19. Primary immunodeficiencies: genotype–phenotype correlations
20. Transcriptional profiling of dentritic cells in response to pathogens
21. Parallel biology: a systematic approach to drug target and biomarker discovery in chronic obstructive pulmonary disease
22. Mycobacterial granulomas: a genomic approach

Index

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