by Derek LeRoith,
Walter Zumkeller
and Robert C. Baxter

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets.

Insulin-Like Growth Factors is a comprehensive reference guide that contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Contents

1. The Structure of the Type 1 Insulin-Like Growth Factor Receptor
2. Structure and Function of the IGF-1 and Mannose
3. IGFBPs—Gene and Protein Structure
4. Regulation of Insulin-Like Growth Factor-I Gene Expression
5. The Many Levels of Control of IGF-II Expression
6. IGF-I Receptor Signaling in Health and Disease
7. Insulin-Like Growth Factor-I Stimulation of Growth: Autocrine, Paracrine and/or Endocrine Mechanisms of Action?
8. Insulin-Like Growth Factor 1 (IGF1) and Brain Development
9. IGFs and the Nervous System
10. The Insulin-Like Growth Factors in Mammary Development and Breast Cancer
11. The Insulin-Like Growth Factor System and Bone
12. IGFBP-5, a Multifunctional Protein, Is an Important Bone Formation Regulator
13. IGF Action and Skeletal Muscle
14. Insulin-Like Growth Factor-I and the Kidney
15. IGF-Independent Effects of the IGFBP Superfamily
16. Functional Relationships between Transforming Growth Factor-&beta and the Insulin-Like Growth Factor Binding Proteins
17. Insulin-Like Growth Factor Binding Proteins (IGFBPs) and Apoptosis
18. The Role of Insulin-Like Growth Factor-1 and Extracellular Matrix Protein Interaction in Controlling Cellular Responses to this Growth Factor
19. Epidemiologic Approaches to Evaluating Insulin-Like Growth Factor and Cancer Risk
20. IGF-I, Insulin and Cancer Risk: Linking the Biology and the Epidemiology
21. The Molecular Basis of IGF-I Receptor Gene Expression in Human Cancer
22. Antisense and Triple Helix Strategies in Basic and Clinical Research: Challenge for Gene Therapy of Tumors Expressing IGF-I
23. The IGF System in Breast Cancer
24. The Role of the IGF System in Prostate Cancer
25. IGFs and Sarcomas
26. IGFs and Epithelial Cancer
27. Insulin-Like Growth Factors and Hematological Malignancies
28. Metabolic Effects of Insulin-Like Growth Factor I and Growth Hormone in vivo: A Comparison
29. Insulin-Like Growth Factor II (IGF-II) and Non-Islet Cell Tumor Hypoglycemia (NICTH)
30. Diabetes
31. Insulin-Like Growth Factors in Critical Illness
32. Laron Syndrome: Primary GH Insensitivity or Resistance

Index

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