edited by Colin Sanderson

This important volume describes the latest advances in all areas of interleukin-5 (IL5) research, pooling the insights of over 65 biological researchers, pharmaceutical scientists, and clinicians, representing institutions as diverse as the Mayo Clinic, the National Lung and Heart Institute, the John Curtin School of Medical Research, the Geneva Biomedical Research Institute, the Flanders' Interuniversity Institute for Biotechnology, and the University of Tokyo.

Details IL5-related antiallergy drugs currently in development at Glaxo Wellcome and Schering-Plough Research Institute!

Reviewing approaches toward small molecule antagonists and inhibitors, Interleukin-5:

• Highlights the structure and function of IL5 and IL5 receptors
• Explores the interaction between IL5 and eotaxin
• Analyzes agents that down-regulate IL5 production
• Evaluates studies on IL5 knockout and transgenic mice
• Outlines the regulation of IL5 gene expression
• Discusses the protein structure of IL5
• Covers the signalling pathways used by the IL5 receptor
• Relates the structure and role of receptor subunits in signal transduction
• And more!

Featuring over 1250 references, tables, drawings, photographs, and micrographs, Interleukin-5 is suitable for pulmonologists and pulmonary disease specialists; immunologists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and medical school students in these disciplines.

Contents

1. The Eosinophil and Bronchial Asthma: Evidence for a Critical Role of Eosinophils in Pathophysiology
2. Interleukin-5 in Rhinitis: Influence of Treatment
3. Interleukin-5 and Interleukin-5 Receptor in Asthma
4. Bone Marrow in Allergic Disease: The Role of Interleukin-5 as an Eosinophilopoietic Factor
5. Eosinophils, Interleukin-5, and Cutaneous Disease
6. Perinatal and Early Childhood Cytokine Responses to Environmental Allergens
7. The Role of Interleukin-5 in Allergic Airways Disease
8. Cytokine Control of the Development of a T-Helper 2 Response
9. Interactions Between Interleukin-5 and the Eosinophil-Selective Chemokine Eotaxin: Potential Relevance in Allergic Disease
10. Structure of Interleukin-5
11. The Structural Basis for Interleukin-5 Receptor Assembly
12. Analysis of the Expression Pattern of Human Interleukin-5 Receptor Isoforms In Vitro
13. Role of the Common Subunit of the Interleukin-3, Interleukin-5, and Granulocyte Macrophage-Colony Stimulating Factor Receptors
14. Interleukin-5 Receptor and Signal Transduction
15. Regulation of Interleukin-5 Gene Expression
16. Regulation of Interleukin-5 Expression in T Lymphocytes: Repression by Dexamethasone
17. Interleukin-5 and the Interleukin-5 Receptor: Targets for Drug Discovery in Asthma
18. Pulmonary Biology of Anti-Interleukin-5 Antibodies

click here to see books • videos • cd-roms of related interest