Introduction to Biochemical Toxicology
Third Edition
by Ernest Hodgson and Robert Smart

Recent applications of new molecular and cellular techniques have expanded our knowledge of how toxicants produce their adverse effects. As a consequence, the time has come for a substantial revision of Professor Ernest Hodgson’s classic reference in the field.

This Third Edition now contains updated overview chapters on immunochemical and molecular techniques. It also features entirely new chapters covering such crucial topics as immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology.

Contents

1. Biochemical Toxicology: Definition and Scope
2. Overview of Molecular Techniques in Toxicology: Genes/Transgenes
3. Immunochemical Techniques in Toxicology
4. Overview of Cellular Techniques in Toxicology
5. Metabolism of Toxicants: Phase I Reactions and Pharmacogenetics
6. Conjugation and Elimination of Toxicants
7. Physiological Factors Affecting Xenobiotic Metabolism
8. Adaptation to Toxicants
9. Reactive Metabolities and Toxicity
10. Mechanisms of Chemically Induced Cell Injury and Cellular Protection Mechanisms
11. Nutritional Factors
12. Toxicant-Receptor Interactions: Fundamental Principles
13. Effects of Toxicants on Electron Transport and Oxidative Phosphorylation
14. Effects of Toxicants on Nucleic Acid and Protein Metabolism
15. Carcinogenesis
16. Genetic Toxicology
17. Molecular Epidemiology
18. Biochemical Toxicology of the Peripheral Nervous System
19. Biochemical Toxicology of the Central Nervous System
20. Hepatotoxicity
21. Dermatotoxicology
22. Reproductive and Developmental Toxicity
23. Immunotoxicity
24. Respiratory Tract Toxicity
25. Biochemical Mechanisms of Renal Toxicity
26. Cardiovascular Toxicity

Index

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