Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biological, and environmental sciences.

Features:

• Introduces biological and environmental applications such as examination of enzyme mechanisms and hydrogen tunneling
• Addresses equilibrium isotope effects, isotope effects on hydrogen bond structure and dynamics, and isotopes in polymers and biopolymers
• Examines isotope effects in chemical dynamics, hydrogen isotope effects in organic reactions, and atmospheric, geologic, and extraterrestrial studies

Contents

• Theoretical Basis of Isotope Effects from an Autobiographical Perspective
• Enrichment of Isotopes
• Comments on Selected Topics in Isotope Theoretical Chemistry
• Condensed Matter Isotope Effects
• Anharmonicities, Isotopes, and IR and NMR Properties of Hydrogen-Bonded Complexes
• Isotope Effects on Hydrogen-Bond Symmetrization in Ice and Strong Acids at High Pressure
• Hydrogen Bond Isotope Effects Studied by NMR
• Isotope Effects and Symmetry of Hydrogen Bonds in Solution: Single- and Double-Well Potential
• NMR Studies of Isotope Effects of Compounds with Intramolecular Hydrogen Bonds
• Vibrational Isotope Effects in Hydrogen Bonds
• Isotope Selective Infrared Spectroscopy and Intramolecular Dynamics
• Nonmass-Dependent Isotope Effects
• Isotope Effects in the Atmosphere
• Isotope Effects for Exotic Nuclei
• Muonium - An Ultra-Light Isotope of Hydrogen
• The Kinetic Isotope Effect in the Photo-Dissociation Reaction of Excited-State Acids in Aqueous Solutions
• The Role of an Internal-Return Mechanism on Measured Isotope Effects
• Vibrationally Enhanced Tunneling and Kinetic Isotope Effects in Enzymatic Reactions
• Kinetic Isotope Effects for Proton-Coupled Electron Transfer Reactions
• Kinetic Isotope Effects in Multiple Proton Transfer
• Interpretation of Primary Kinetic Isotope Effects for Adiabatic and Nonadiabatic Proton-Transfer Reactions in a Polar Environment
• Variational Transition-State Theory and Multidimensional Tunneling for Simple and Complex Reactions in the Gas Phase, Solids, Liquids, and Enzymes
• Computer Simulations of Isotope Effects in Enzyme Catalysis
• Oxygen-18 Isotope Effects as a Probe of Enzymatic Activation of Molecular Oxygen
• Solution and Computational Studies of Kinetic Isotope Effects in Flavoprotein and Quinoprotein Catalyzed Substrate Oxidations as Probes of Enzymic Hydrogen Tunneling and Mechanism
• Proton Transfer and Proton Conductivity in Condensed Matter Environment
• Mechanisms of CH-Bond Cleavage Catalyzed by Enzymes
• Kinetic Isotope Effects as Probes for Hydrogen Tunneling in Enzyme Catalysis
• Hydrogen Bonds, Transition-State Stabilization, and Enzyme Catalysis
• Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions
• Catalysis by Alcohol Dehydrogenases
• Effects of High Hydrostatic Pressure on Isotope Effects
• Solvent Hydrogen Isotope Effects in Catalysis by Carbonic Anhydrase: Proton Transfer through Intervening Water Molecules
• Isotope Effects from Partitioning of Intermediates in Enzyme-Catalyzed Hydroxylation Reactions
• Chlorine Kinetic Isotope Effects on Biological Systems
• Nucleophile Isotope Effects
• Enzyme Mechanisms from Isotope Effects
• Catalysis and Regulation in the Soluble Methane Monooxygenase System: Applications of Isotopes and Isotope Effects
• Secondary Isotope Effects
• Isotope Effects in the Characterization of Low Barrier Hydrogen Bonds
• Theory and Practice of Solvent Isotope Effects
• Enzymatic Binding Isotope Effects and the Interaction of Glucose with Hexokinase

Index

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