Liposomes covers the basics of liposomology, offering insights from over 30 scientists involved in its growth and considering the direction of future developments.

Features:

• Discusses the design of clinical trials
• Analyzes morphological diversity and functionality in gene delivery
• Highlights antitumor activities of lipids acting as second messengers
• Suggests how antibodies to cholesterol can be used therapeutically
• Explores applications of liposomes with high captured volumes
• Details the clinical detection of antilipid antibodies
• Addresses the lyophilization of liposomes

Contents

• Steric Stabilization: An Overview
• Surface Chemistry of the Sterically Stabilized PEG-Liposome: General Principles
• Liposome Pharmacokinetics: Classical, Sterically Stabilized, Cationic Liposomes and Immunoliposomes
• Functional Pleomorphism of Liposomal Gene Delivery Vectors: Lipoplex and Lipopolyplex
• Antitumor Ether Lipids: Biological and Biochemical Effects
• The Antitumor Properties of Ceramide
• Antibodies to Cholesterol: Principles for Practical Application
• Clinical Detection of Antiphospholipid Antibodies
• Liposome-Mediated DNA Vaccination
• Applications of Liposomes with High Captured Volume
• Lyophilization of Liposomes
• Dermatological Applications of Liposomes
• Preclinical Development Issues for Lipid-Based Pharmaceuticals
• Liposomal Doxorubicin: From Basics to Clinical Approval
• Clinical Evaluation of Liposomal Anthracyclines
• Liposomes and Acute Lung Injury
• Liposome-Based Patents for Use in the Pharmaceutical Industry

Index

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